| | Author, year [reference] | Receptor | | Location | Nontumor (nonneoplastic urothelium) versus tumor | Tumor grade | Tumor stage |
Prognostic significance ( value) | | Non-Tumor | Tumor | value | LG | HG | value | NMI | MI | value |
| |
Boorjian et al., 2004 [36] | AR | 49 | Bladder | 86% | 53% | 0.001 | 89% | 49% | 0.055 | 75% | 21% | 0.002 | NA | |
Boorjian et al., 2009 [25] | AR | 55 | Bladder | NA | 44% | 0.06 | NA | NA | NA | 59% | 33% | 0.095 | NA | |
Kauffman et al., 2011 [37] | AR | 59 | Bladder | 84% | Roughly half | <0.001 | NA | NA | NA | NA | NA | 0.028
(NMI > MI) | NS | |
Mir et al., 2011 [38] | AR | 472 | Bladder | NA | 13% | NA | 12% | 13% | 0.83 | 9% | 15% | 0.058 | NS | |
Rau et al., 2011 [39] | AR | 93 | UUT | NA | NA | NA | NA | NA | 0.074
(LG > HG) | NA | NA | 0.001
(stage II > I) | 0.568 | |
Tuygun et al., 2011 [30] | AR | 139 | Bladder | 0% (M) | 51% | <0.001 | 64% | 37% | 0.002 | 60% | 21% | <0.001 | 0.095 (RFS)
0.110 (PFS) | |
Miyamoto et al., 2012 [40] | AR | 188 | Bladder | 80% | 42% | <0.001 | 55% | 36% | 0.023 | 51% | 33% | 0.018 | 0.071 (PFS/MI) | |
Shyr et al., 2013 [41] | AR | 83 | UUT | NA | 55% | NA | 69% | 47% | 0.070 | 63% | 44% | 0.114 | NA | |
Jing et al., 2014 [42] | AR | 58 | Bladder | NA | 53% | NA | 55% | 50% | 0.724 | 49% | 69% | 0.195 | NA | |
Mashhadi et al., 2014 [43] | AR | 120 | Bladder | 0% | 22% | <0.001 | NA | NA | <0.001 | NA | NA | <0.001 | 0.02 | |
Nam et al., 2014 [44] | AR | 169 | Bladder | NA | 37% | NA | 39% | 33% | 0.269 | 43% (Ta)
30% (T1) | NA | 0.048
(Ta vs T1) | 0.001 (RFS)
0.288 (PFS) | |
Williams et al., 2015 [45] | AR | 297 | Bladder | NA | 25% | NA | NA | NA | NA | 33% (Ta/Tis) | 19% (T1–3) | 0.010 | NA | | Williams et al., 2015 [45] | AR | 43 | UUT | NA | 16% | NA | NA | NA | NA | NA | NA | NA | NA | |
Kashiwagi et al., 2015 [46], and unpublished data | AR | 99 | UUT | 58% | 20% | <0.001 | 33% | 18% | 0.177 | 14% | 24% | 0.301 | NS |
| |
Shen et al., 2006 [52] | ER | 224 | Bladder | NA | 1% | NA | NA | NA | NA | NA | NA | NA | NA | |
Bolenz et al., 2009 [53] | ER | 198 | Bladder | NA | 5% | 0.06 | NA | NA | NA | NA | NA | 0.004 (OC > non-OC) | NS | | Miyamoto et al., 2012 [40] | ER | 188 | Bladder | 50% | 27% | <0.001 | 38% | 23% | 0.048 | 35% | 19% | 0.014 | NS | | Mashhadi et al., 2014 [43] | ER | 120 | Bladder | 2% | 3% | 0.67 | NA | NA | NA | NA | NA | NA | NA | |
Tan et al., 2015 [54] | ER | 410 | Bladder | NA | 4% | NA | NA | NS | NA | NA | NS | NA | NA | | Kashiwagi et al., 2015 [46], and unpublished data | ER | 99 | UUT | 40% | 18% | 0.001 | 27% | 17% | 0.465 | 11% | 23% | 0.183 | NS |
| |
Croft et al., 2005 [55] | ER | 92 | Bladder | NA | 11–22% | NA | 6–12% (G1-2) | 17–33% (G3) | 0.021–0.177 | 5–9% (Ta) | 16–33% (≥T1) | 0.010–0.098 | NA | | Shen et al., 2006 [52] | ER | 224 | Bladder | NA | 63% | NA | 58% (G1-2) | 70% (G3) | 0.085 | 54% | 80% | <0.001 | NA | |
Kontos et al., 2010 [56] | ER | 111 | Bladder | 93% | 76% | 0.041 | 95% (G1-2) | 56% (G3) | <0.001 | 83% (T1) | 54% | 0.011 | NA | | Tuygun et al., 2011 [30] | ER | 139 | Bladder | 0% (M)
36% (F) | 27–30% | <0.001 | 22–26% | 31–34% | 0.44–0.59 | 24–26% | 36–42% | 0.16–0.24 | 0.114 (RFS)
0.025 (PFS) | | Miyamoto et al., 2012 [40] | ER | 188 | Bladder | 89% | 49% | <0.001 | 29% | 58% | <0.001 | 34% | 67% | <0.001 | 0.007 (PFS/LG)
≤0.001 (PFS)
0.007 (CSS/MI) | |
Kauffman et al., 2013 [57] | ER | 72 | Bladder | NA | NA | <0.001
(N < T) | NA | NA | NA | NA | NA | NS | 0.030 (RFS)
0.0018 (CSS) | | Shyr et al., 2013 [41] | ER | 83 | UUT | NA | 43% | NA | 44% | 43% | 1.000 | 51% | 47% | 0.815 | NA | | Nam et al., 2014 [44] | ER | 169 | Bladder | NA | 31% | NA | 27% | 41% | 0.043 | 22% (Ta)
42% (T1) | NA | 0.004
(Ta vs T1) | 0.004 (RFS)
0.014 (PFS) | | Tan et al., 2015 [54] | ER | 410 | Bladder | NA | 100% | NA | 100% | 100% | NS | 100% | 100% | NS | 0.055/0.087 (CSS) | | Kashiwagi et al., 2015 [46], and unpublished data | ER | 99 | UUT | 85% | 63% | 0.001 | 73% | 61% | 0.402 | 65% | 63% | 1.000 | NS |
| |
Ishiguro et al., 2014 [62] | GR | 149 | Bladder | 96% | 87% | 0.026 | 96% | 81% | 0.011 | 96% | 74% | <0.001 | 0.025 (RFS/NMI)
0.030 (PFS/MI)
0.067 (CSS/MI) | | Kashiwagi et al., 2015 [46], and unpublished data | GR | 99 | UUT | 84% | 63% | 0.001 | 53% | 64% | 0.563 | 62% | 63% | 1.000 | NS |
| | Bolenz et al., 2009 [53] | PR | 198 | Bladder | NA | 0% | NA | NA | NA | NA | NA | NA | NA | NA | | Mashhadi et al., 2014 [43] | PR | 120 | Bladder | 2% | 4% | 0.48 | NA | NA | NA | NA | NA | NA | NA | | Tan et al., 2015 [54] | PR | 410 | Bladder | NA | 0% | NA | 0% | 0% | NS | 0% | 0% | NS | NA | | Kashiwagi et al., 2015 [46], and unpublished data | PR | 99 | UUT | 13% | 16% | 0.487 | 7% | 18% | 0.453 | 14% | 18% | 0.779 | 0.041 (CSS/pT3-4) |
| |
Hermann and Andersen, 1997 [70] | VDR | 26 | Bladder | NA | 100% | NA | 100% | 100% | 0.043
(LG < HG) | 100% | 100% | 0.051
(NMI < MI) | NA | |
Sahin et al., 2005 [71] | VDR | 105 | Bladder | 67% | 86% | 0.02 | 81% (G1) | 91% (G2-3) | NS | 85% (Ta)
87% (T1) | NA | NS | 0.001 (PFS) |
| |
Inamoto et al., 2010 [85] | Nurr1 | 145 | Bladder | 0% (high) | 100%
65% (high) | NA | 35% (high; G1-2) | 92% (high; G3) | <0.001 | 47% (high) | 92% (high; including T1b) | <0.001 | <0.001 (RFS)
<0.001 (CSS) |
|
|
