First-Trimester Serum Acylcarnitine Levels to Predict Preeclampsia: A Metabolomics Approach
Table 1
Baseline characteristics of the study population (adapted from Kuc et al. [13]).
Characteristics
Controls
EO-PE
LO-PE
n = 500
n = 68
n = 99
Maternal age (y)
33 (30–35)
34 (30–37)
33 (30–36)
Maternal weight (kg)
65.5 (60.0–73.0)
70.0 (62.0–81.5)
67.5 (62.0–75.0)
Maternal BMI (kg/m2)
22.8 (20.7–24.8)
24.7 (21.9–29.3)
23.7 (21.3–26.5)
Nulliparity
233 (46.6)
55 (80.9)
72 (72.7)
Smoking
21 (4.2)
8 (11.8)
6 (6.1)
Assisted reproduction
0 (0)
3 (4.4)
8 (8.1)
Gestation at sampling (days)
88 (84–91)
85 (76–89)
85 (79–89)
History of hypertensive pregnancy disorders†
4 (1.5)
4 (30.8)
10 (37.0)
Gestational age at birth (wk)
40 (39–41)
31 (30–32)
37 (36–39)
Birth weight (grams)
3544 (3243–3800)
1300 (1045–1609)
2650 (2130–3110)
Birth weight centile
57.0 (33.1–78.4)
25.0 (13.4–50.4)
13.8 (3.8–46.0)
Fetal gender, male
244 (48.8)
34 (49.7)
53 (53.5)
Values are presented as median and interquartile ranges or numbers and percentages. Mann-Whitney test and chi-square test, both with post hoc Bonferroni correction (adjusted significance value ), were used for statistical comparison between EO-PE women, LO-PE women, and controls. †Percentage based on multiparous women only. Significantly different from controls. ‡Significantly different between EO-PE and LO-PE. EO-PE: early-onset-preeclampsia; LO-PE: late-onset-preeclampsia; BMI: body mass index.
