First-Trimester Serum Acylcarnitine Levels to Predict Preeclampsia: A Metabolomics Approach
Table 2
List of acylcarnitines that were measured in this study with accompanying fold changes, values, and false discovery rates (FDR).
Metabolite
EO-PE versus controls
LO-PE versus controls
Selection
Ratio
value
FDR
Ratio
value
FDR
Choline
0.983
0.824
0.827
0.998
0.971
0.971
Betaine
1.013
0.788
0.827
1.032
0.406
0.513
Deoxycarnitine
0.944
0.082
0.140
0.971
0.265
0.374
Carnitine
1.009
0.758
0.827
1.045
0.094
0.173
Acetylcarnitine
0.947
0.501
0.707
0.910
0.136
0.218
Propionylcarnitine
0.910
0.055
0.102
0.996
0.928
0.971
Isobutyrylcarnitine
0.822
0.006
0.015
0.958
0.436
0.523
EO-PE
2-Methylbutyroylcarnitine
1.016
0.761
0.827
1.041
0.299
0.398
Isovalerylcarnitine
1.038
0.613
0.774
1.110
0.083
0.166
Hexanoylcarnitine
1.234
0.008
0.016
1.114
0.044
0.095
Both
Octenoylcarnitine
1.281
<0.001
0.004
1.240
<0.001
0.004
Both
Octanoylcarnitine
1.378
0.001
0.005
1.201
0.020
0.054
Both
Nonaylcarnitine
0.903
0.242
0.363
0.967
0.644
0.736
Decenoylcarnitine
1.253
0.001
0.005
1.198
0.001
0.004
Both
Decanoylcarnitine
1.423
0.001
0.004
1.200
0.031
0.074
Both
Dodecenoylcarnitine
1.272
0.003
0.008
1.162
0.015
0.050
Both
Lauroylcarnitine
1.328
0.002
0.007
1.108
0.152
0.228
EO-PE
Tetradecenoylcarnitine
1.493
<0.001
0.001
1.248
0.017
0.052
Both
Myristoylcarnitine
1.032
0.558
0.744
0.921
0.121
0.208
Hexadecenoylcarnitine
1.189
0.007
0.016
0.996
0.954
0.971
EO-PE
Linoleylcarnitine
0.849
0.004
0.011
0.851
0.002
0.007
Both
Palmitoylcarnitine
0.992
0.827
0.827
0.896
0.002
0.007
LO-PE
Oleylcarnitine
0.922
0.089
0.143
0.856
0.001
0.007
LO-PE
Stearoylcarnitine
0.829
<0.001
0.001
0.842
<0.001
<0.001
Both
Fold changes (ratio) were calculated based on log-transformed data and Student’s -tests were used for comparison. values were corrected for multiple testing by calculating FDR. Metabolites with a FDR <10% for both EO-PE and LO-PE were selected for fitting prediction models. EO-PE: early-onset-preeclampsia; LO-PE: late-onset-preeclampsia.
