Research Article
The Role of Circulating Tight Junction Proteins in Evaluating Blood Brain Barrier Disruption following Intracranial Hemorrhage
Table 5
Receiver operating characteristic curve analysis of the intracranial hemorrhage group.
| | | AUC | p | Cut-off value | Sensitivity | Specificity | PPV | NPV |
| | ZO-1 (pg/mL) | 0.992 | 0.000 | 374.21 | 95.50 | 94.10 | 95.50 | 94.10 | | OCLN (pg/mL) | 0.960 | 0.000 | 2.19 | 95.50 | 94.10 | 95.50 | 94.10 | | CLDN5 (pg/mL) | 0.930 | 0.000 | 409.18 | 81.80 | 94.10 | 94.74 | 80.00 | | MMP-9 (ng/mL) | 0.930 | 0.000 | 0.19 | 81.80 | 94.10 | 94.70 | 80.00 | | SBP (mmHg) | 0.898 | 0.000 | 159.50 | 77.30 | 94.10 | 94.70 | 80.00 | | ALB (g/L) | 0.896 | 0.000 | 0.50 | 90.90 | 82.40 | 87.00 | 87.50 | | DBP (mmHg) | 0.893 | 0.000 | 95.00 | 77.30 | 94.10 | 94.40 | 76.20 | | VEGF (ng/mL) | 0.869 | 0.000 | 11.28 | 90.90 | 82.40 | 87.00 | 87.50 | | WBC (/L) | 0.837 | 0.000 | 22.50 | 86.40 | 64.70 | 76.00 | 78.60 | | OCLN (pg/mL) | 0.567 | 0.479 | 11.72 | 54.50 | 88.20 | 86.70 | 62.50 | | ZO-1 (pg/mL) | 0.432 | 0.470 | 2344.28 | 36.40 | 82.40 | 72.70 | 50.00 | | CLDN5 (pg/mL) | 0.251 | 0.008 | 68.25 | 86.40 | 11.80 | 90.50 | 83.30 |
|
|
AUC: areas under curve; PPV: positive predictive value; NPV: negative predictive value; CLDN5: serum Claudin-5; OCLN: serum Occludin; ZO-1: serum ZO-1; CSF: cerebrospinal fluid; CLDN5: Claudin-5 in CSF; OCLN: OCLN in CSF; ZO-1: ZO-1 in CSF; VEGF: vascular endothelial growth factor; MMP-9: metalloproteinases; SBP: systolic blood pressure; DBP: diastolic blood pressure.
|
