NRAMP1 and VDR Gene Polymorphisms in Susceptibility to Tuberculosis in Venezuelan Population
Table 1
Genotype and allele frequency distribution of NRAMP1 gene in the controls and TB patients.
INT4
CC
GC
GG
Total
Genotypes
Controls (number of individuals)
14
45
39
98
% of total
7.49
24.06
20.86
52.41
% within condition
14.29
45.92
39.80
% within INT4
60.87
56.25
46.43
TB patients (number of individuals)
9
35
45
89
% of total
4.81
18.72
24.06
47.59
% within condition
10.11
39.33
50.56
% within INT4
39.13
43.75
53.75
Total
23
80
84
187
% of total
12.30
42.78
44.92
100
(df: 2) = 2.34 Cramer’s
D543
AA
AG
GG
Total
Genotypes
Controls (number of individuals)
1
10
89
100
% of total
0.52
5.21
46.35
52.08
% within condition
1
10
89
% within D543
25
55.56
52.35
TB patients (number of individuals)
3
8
81
92
% of total
1.56
4.17
42.19
47.92
% within condition
3.3
8.7
88
% within D543
75
44.44
47.65
Total
4
18
170
192
% of total
2.08
9.38
88.54
100
(df: 2) = 1.27 Cramer’s
3'UTR
TGTGdel/del
TGTG+/del
TGTG+/+
Total
Genotypes
Controls (number of individuals)
0
21
79
100
% of total
0.00
11.11
41.80
52.91
% within condition
0.00
21.00
79.00
% within 3'UTR
0.00
42.00
58.09
TB patients (number of individuals)
3
29
57
89
% of total
1.59
15.34
30.16
47.09
% within condition
3.37
32.58
64.04
% within 3'UTR
100.00
58.00
41.91
Total
3
50
136
189
% of total
71.96
26.46
1.59
100
(df: 2) = 7.22 Cramer’s
Note. : probability values; + = presence of TGTG; del = absence of these four bases; df: degree freedom; Cramer’s : measure of association between two variables.
