Association of DNA Repair Gene APE1 Asp148Glu Polymorphism with Breast Cancer Risk

Figure 3

(a) Ribbon diagram of APE1 protein showing all the three side chains A, B, and C. (b) APE1 structure superimposed with wild-type and mutant residue with mutation Asp148Glu enlarged. (c) Molecular dynamics (MD) simulation showing truncated octahedron boundary explicit water solvated and hydrogen atoms. The visual inspection also allows identifying the side chain of Glu residues involved in hydrogen bonding with the surrounding molecules.