Association of DNA Repair Gene APE1 Asp148Glu Polymorphism with Breast Cancer Risk

Table 3

Genotype frequencies of APE1 gene polymorphism in below 48 and above 48 years of age of breast cancer cases and controls.

Genotype	Cases	Controls	OR	95% CI		value
rs1130409	Below 48
Asp/Asp	7 (0.148)	16 (0.275)	Ref
Asp/Glu	24 (0.510)	26 (0.448)	2.110	0.740–6.013	1.99	0.15841
Glu/Glu	16 (0.340)	16 (0.275)	2.286	0.741–7.051	2.11	0.14678
Asp/Glu + Glu/Glu	40 (0.851)	42 (0.724)	2.177	0.810–5.847	2.44	0.11790
Asp	38 (0.404)	58 (0.5)	Ref
Glu	56 (0.595)	58 (0.5)	1.474	0.851–2.553	1.92	0.16607
rs1130409	Above 48
Asp/Asp	5 (0.094)	11 (0.261)	Ref
Asp/Glu	21 (0.396)	20 (0.476)	2.310	0.68–7.84	1.85	0.17378
Glu/Glu	27 (0.509)	11 (0.261)	5.400	1.52–19.20	7.39	0.00656
Asp/Glu + Glu/Glu	48 (0.905)	31 (0.738)	3.406	1.08–10.75	4.70	0.03021
Asp	31 (0.292)	42 (0.5)	Ref
Glu	75 (0.707)	42 (0.5)	2.419	1.33–4.40	8.53	0.00349