Association of DNA Repair Gene APE1 Asp148Glu Polymorphism with Breast Cancer Risk

Table 5

Allele and genotype frequencies of APE1 rs1130409 (Asp148Glu) in central Saudi Arabia and other populations.

Population	Genotype freq. (number)			Allele frequency		Pairwise test value between CRS & other populations	value
	Asp/Asp freq. (number)	Asp/Glu freq. (number)	Glu/Glu freq. (number)	Wild type; Asp	Variant; Glu
CEU ()	0.319	0.407	0.274	0.52	0.48	0.13	0.71
CHB ()	0.214	0.476	0.310	0.45	0.55	0.41	0.51
JPT ()	0.094	0.494	0.412	0.34	0.66	6.61	0.01
GIH ()	0.114	0.341	0.545	0.28	0.72	12.86	0.0003
YRI ()	0.133	0.381	0.487	0.32	0.68	9.24	0.002
MKK ()	0.098	0.524	0.378	0.36	0.64	6.05	0.01
TSI ()	0.230	0.448	0.322	0.45	0.55	0.53	0.46
CRS ()	0.27	0.46	0.27	0.50	0.50	Ref	—

Population descriptions:
CEU: Utah residents with Northern and Western European ancestry from the CEPH collection.
CHB: Han Chinese in Beijing, China.
JPT: Japanese in Tokyo, Japan.
GIH: Gujarati Indians in Houston, Texas.
YRI: Yoruba in Ibadan, Nigeria.
MKK: Maasai in Kinyawa, Kenya.
TSI: Toscans in Italy.
CRS: Saudi population residing in Riyadh region of central Saudi Arabia.
values significant after Bonferroni correction.