Aerobic Glycolysis as a Marker of Tumor Aggressiveness: Preliminary Data in High Grade Human Brain Tumors

Figure 1

Coregistered PET and MR images from an individual with glioblastoma (participant #1). ((a)–(f)) MR and PET images of the same tomographic slice demonstrating the tumor region: (a) FLAIR MR image; (b) Apparent Diffusion Coefficient (ADC) diffusion-weighted MR image; (c) Cerebral Blood Volume (CBV) perfusion-weighted MR image; (d) CMRGlu PET image; (e) CMRO₂ PET image; (f) CBF PET image; ((g)-(h)) biopsy sites (showed with red circles) in tumor (left and middle) and peritumoral (right) regions: (g) T1-weighted MR images with contrast (Gadolinium) enhancement; (h) AG PET images. ((i)-(j)) Histopathology for the corresponding biopsy sites: (i) Ki-67 labeling and (j) Hematoxylin and eosin stained sections.