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Disease Markers
Volume 2015, Article ID 918968, 7 pages
Clinical Study

High-Dose versus Low-Dose Vitamin D Supplementation and Arterial Stiffness among Individuals with Prehypertension and Vitamin D Deficiency

1Division of Cardiology, Hartford Hospital, Hartford, CT 06102, USA
2Department of Kinesiology, University of Connecticut, Storrs, CT 06069, USA
3Cardiology Division, Department of Medicine, University of Alabama, Birmingham, AL 16686, USA
4Cardiovascular Research Center and Center for Human Genetic Research, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02115, USA
5Division of Cardiovascular Medicine, Vanderbilt University Medical Center, Nashville, TN 37201, USA

Received 26 June 2015; Accepted 2 September 2015

Academic Editor: Karin Amrein

Copyright © 2015 Amanda Zaleski et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Introduction. Vitamin D deficiency is associated with the onset and progression of hypertension and cardiovascular disease (CVD). However, mechanisms underlying vitamin D deficiency-mediated increased risk of CVD remain unknown. We sought to examine the differential effect of high-dose versus low-dose vitamin D supplementation on markers of arterial stiffness among ~40 vitamin D deficient adults with prehypertension. Methods. Participants were randomized to high-dose (4000 IU/d) versus low-dose (400 IU/d) oral vitamin D3 for 6 months. 24 hr ambulatory blood pressure (BP), carotid-femoral pulse wave velocity, and pulse wave analyses were obtained at baseline and after 6 months of vitamin D supplementation. Results. There were no changes in resting BP or pulse wave velocity over 6 mo regardless of vitamin D dose (all ). High-dose vitamin D decreased augmentation index and pressure by 12.3 ± 5.3% () and 4.0 ± 1.5 mmHg (), respectively. However, these decreases in arterial stiffness were not associated with increases in serum 25-hydroxyvitamin D over 6 mo (). Conclusion. High-dose vitamin D supplementation appears to lower surrogate measures of arterial stiffness but not indices of central pulse wave velocity. Clinical Trial Registration. This trial is registered with (Unique Identifier: NCT01240512).