Metabolic Serum Profiles for Patients Receiving Allogeneic Stem
Cell Transplantation: The Pretransplant Profile Differs for
Patients with and without Posttransplant Capillary Leak Syndrome
Table 1
Patients with and without capillary leak syndrome: a comparison of clinical characteristics.
Weight increase
All patients
<5 kg ()
≥5 kg ()
value
Demographic data
Age (years)
44 (15–69)
42 (15–69)
51 (20–67)
0.1066
Gender (female/male)
29/51
13/26
16/25
0.5966
Weight (kg)
71.4 (41.5–110)
73 (41.5–110)
70 (46.5–133)
0.7031
Height (cm)
176 (149–197)
179 (149–193)
174 (158–197)
0.4102
BMI (kg/m2)
23.2 (16.6–39.7)
23.5 (16.6–36.5)
23.1 (17.9–39.7)
0.2852
Diagnosis
AML
35
19
16
MDS
15
5
10
ALL
18
11
7
CML
4
1
3
CMML
2
0
2
CLL
1
1
0
PMF
2
1
1
AA
3
0
3
Body weight
Weight increase (kg)
5.0 (0–16.1)
3.2 (0–4.8)
7.0 (5.0–16.1)
<0.0001
Day of maximal weight
6 (−8–44)
−1 (−8–13)
9 (−5–44)
0.0011
Acute GVHD (yes/no)
42/28
24/12
18/16
0.2414
Reconstitution
Neutrophil (day post-SCT)
15 (6–52)
15 (6–29)
16 (11–52)
0.2848
Platelets (day post-SCT)
15 (9–33)
14 (9–29)
16 (9–33)
0.2076
Baseline pretransplant status
Leukocytes (×109/L)
3.9 (0.5–44.3)
3.5 (0.7–11.8)
4.8 (0.5–44.3)
0.1972
Hb (g/dL)
10.5 (7.8–14.1)
10.6 (7.8–14.0)
10.4 (7.9–14.1)
0.4440
Platelets (×109/L)
143 (10–721)
205 (10–721)
119 (10–554)
0.0147
CRP (mg/L)
5 (1–120)
5 (1–64)
6 (1–120)
0.1660
LDH (IU/dL)
185 (92–1665)
190 (129–489)
174 (92–1665)
0.1780
Unless otherwise stated values are given as median (variation range). Height and weight were registered at the start of conditioning therapy. For statistical analysis the Mann-Whitney test was used to compare continues variables and the Chi-square test for categorical variables. AA, aplastic anemia; ALL; acute lymphoblastic leukemia; AML, acute myelogenous leukemia; BMI, body mass index; MDS, myelodysplastic syndrome; CLL, chronic lymphocytic leukemia; CML, chronic myelogenous leukemia; CMML, chronic myelomonocytic leukemia; CRP, C-reactive protein; GVHD, graft versus host disease; Hb, hemoglobin; LDH, lactate dehydrogenase; PMF, primary myelofibrosis; WBC, white blood cell count.
