Procalcitonin, MR-Proadrenomedullin, and Cytokines Measurement in Sepsis Diagnosis: Advantages from Test Combination

Table 3

Median value, interquartile range (IR) (25th percentile and 75th percentile), and Mann-Whitney comparison of PCT, MR-proADM, and cytokines in sepsis, SIRS, and healthy individuals.

Variable	Sepsis; median (IR)	SIRS; median (IR)	Healthy; median (IR)	Sepsis versus SIRS; Mann-Whitney’s test	Sepsis versus healthy; Mann-Whitney’s test
PCT ng/mL	2.35 (0.47–9.08)	0.12 (0.06–0.25)	0.04 (0.03–0.07)	<0.0001	<0.0001
MR-proADM nmol/L	2.55 (1.59–4.60)	0.77 (0.62–0.86)	0.42 (0.28–0.63)	<0.0001	<0.0001
IL-2 pg/mL	5.02 (2.98–6.97)	5.80 (4.90–7.80)	8.79 (7.15–11.58)	0.047	0.0003
IL-4 pg/mL	1.64 (0.44–2.50)	2.10 (1.53–2.53)	3.65 (3.21–5.08)	n.s.	<0.0001
IL-6 pg/mL	137.1 (52.30–654.78)	16.3 (3.05–52.30)	1.24 (0.73–1.75)	<0.0001	<0.0001
IL-8 pg/mL	21.07 (6.41–69.17)	5.31 (2.59–12.70)	3.49 (2.81–6.01)	<0.0001	<0.0001
IL-10 pg/mL	10.43 (3.31–51.60)	1.51 (0.10–2.85)	0.03 (0.01–1.77)	<0.0001	<0.0001
VEGF pg/mL	64.26 (29.52–134.09)	47.20 (20.08–73.49)	28.20 (46.00–74.20)	0.021	<0.0001
IFN-γ pg/mL	3.78 (1.67–13.03)	2.50 (1.26–4.06)	0.09 (0.02–1.65)	0.0048	<0.0001
TNF-α pg/mL	11.69 (6.83–34.59)	1.94 (1.50–3.78)	2.86 (0.06–3.67)	<0.0001	<0.0001
IL-1α pg/mL	0.21 (0.11–0.46)	0.05 (0.02–0.63)	0.09 (0.02–1.65)	n.s.	0.0003
IL-1β pg/mL	1.25 (0.80–2.86)	0.09 (0.03–1.44)	1.28 (0.08–3.22)	0.0003	n.s.
MCP-1 pg/mL	401.4 (401.42–752.63)	210.76 (14.95–333.08)	158.50 (121.40–196.40)	<0.0001	<0.0001
EGF pg/mL	3.65 (1.54–13.47)	2.88 (0.32–6.90)	4.09 (1.78–11.21)	n.s.	n.s.