Procalcitonin, MR-Proadrenomedullin, and Cytokines Measurement in Sepsis Diagnosis: Advantages from Test Combination

Table 4

Median value, interquartile range (IR) (25th percentile and 75th percentile), and areas under the curves (AUCs) values in Gram-negative sepsis, Gram-positive sepsis, and yeast sepsis.

	Median	Interquartile range	AUC
		(25th percentile and 75th percentile)
Gram-negative sepsis
PCT ng/mL	3.5	1.23–18.43	0.98
MR-proADM nmol/L	2.51	1.40–5.04	0.94
IL-2 pg/mL	5.23	7.34–10.35	0.62
IL-4 pg/mL	1.62	0.43–2.32	0.67
IL-6 pg/mL	168.3	61.00–833.81	0.93
IL-8 pg/mL	31.24	9.56–114.67	0.83
IL-10 pg/mL	18.87	3.33–74.26	0.85
VEGF pg/mL	66.49	33.11–146.39	0.70
IFN-γ pg/mL	6.24	2.49–16.10	0.76
TNF-α pg/mL	21.33	7.61–46.91	0.93
IL-1α pg/mL	0.20	0.10–0.50	0.62
IL-1β pg/mL	1.27	0.91–3.43	0.63
MCP-1 pg/mL	521.33	256.57–990.00	0.85
EGF pg/mL	4.45	2.17–14.05	0.58
Gram-positive sepsis
PCT ng/mL	1.09	0.33–2.62	0.93
MR-proADM nmol/L	2.14	1.69–3.43	0.96
IL-2 pg/mL	4.77	1.41–6.22	0.67
IL-4 pg/mL	0.82	0.35–2.41	0.70
IL-6 pg/mL	103.80	48.00–287.21	0.91
IL-8 pg/mL	10.26	5.29–34.53	0.71
IL-10 pg/mL	5.75	2.34–11.60	0.85
VEGF pg/mL	70.34	29.52–122.10	0.67
IFN-γ pg/mL	2.49	0.32–4.42	0.59
TNF-α pg/mL	7.73	5.86–11.81	0.87
IL-1α pg/mL	0.19	0.11–0.36	0.61
IL-1β pg/mL	0.94	0.09–1.83	0.55
MCP-1 pg/mL	292.37	191.76–492.59	0.74
EGF pg/mL	3.39	1.44–12.59	0.53
Yeast sepsis
PCT ng/mL	1.38	0.24–3.68	0.91
MR-proADM nmol/L	4.74	2.40–8.71	0.97
IL-2 pg/mL	5.76	4.19–45.27	0.51
IL-4 pg/mL	2.15	1.68–3.91	0.56
IL-6 pg/mL	354.68	70.88–850.00	0.92
IL-8 pg/mL	54.96	19.59–87.76	0.92
IL-10 pg/mL	30.57	10.39–155.20	0.92
VEGF pg/mL	48.38	12.74–103.49	0.57
IFN-γ pg/mL	14.59	5.54–37.06	0.85
TNF-α pg/mL	21.52	9.56–42.00	0.89
IL-1α pg/mL	0.34	0.28–0.62	0.63
IL-1β pg/mL	2.25	1.23–13.73	0.75
MCP-1 pg/mL	530.29	355.83–857.90	0.82
EGF pg/mL	2.63	1.64–13.46	0.55