Procalcitonin, MR-Proadrenomedullin, and Cytokines Measurement in Sepsis Diagnosis: Advantages from Test Combination

Table 8

Posttest probability analysis used to define the diagnostic value derived from the combined use of PCT, MR-proADM, IL-6, and TNF-α testing in all sepsis patients and after stratification in Gram-positive sepsis, Gram-negative sepsis, and yeast sepsis.

Markers	All sepsis	Gram-positive	Gram-negative	Yeast
PCT	0.978	0.920	0.960	0.780
ADM	0.930	0.840	0.85	0.763
IL-6	0.810	0.570	0.670	0.250
TNF-α	0.843	0.660	0.790	0.310
Markers association	All sepsis	Gram-positive	Gram-negative	Yeast
PCT + ADM	0.999	0.994	0.995	0.970
PCT + IL-6	0.995	0.977	0.990	0.920
ADM + IL-6	0.980	0.95	0.960	0.750
PCT + TNF-α	0.997	0.982	0.995	0.970
ADM + TNF-α	0.983	0.962	0.975	0.890
ADM + IL-6 + TNF-α	0.996	0.988	0.996	0.966
IL-6 + TNF-α	0.952	0.861	0.901	0.613