Research Article
High CD133 Expression in the Nucleus and Cytoplasm Predicts Poor Prognosis in Non-Small Cell Lung Cancer
Table 1
CD133 expression in cytoplasm and clinicopathological parameters in 239 NSCLC specimens.
| | Group | CD133 expression in nucleus | CD133 expression in cytoplasm | | Low or no expression (%) | High expression (%) | Pearson | value | Low or no expression (%) | High expression (%) | Pearson | value |
| | Total | 102 (42.7) | 137 (57.3) | | | 114 (47.7) | 125 (52.3) | | |
| | Gender | | Female | 29 (49.1) | 30 (50.9) | 1.342 | .247 | 27 (45.8) | 32 (54.2) | 0.118 | .732 | | Male | 73 (40.6) | 107 (59.4) | 87 (48.3) | 93 (51.7) |
| | Age | | ≤60 years | 38 (43.2) | 50 (56.8) | 0.015 | .904 | 41 (46.6) | 47 (53.4) | 0.069 | .793 | | >60 years | 64 (42.4) | 87 (57.6) | 73 (48.3) | 78 (51.7) |
| | Tumor diameter | | ≤4 cm | 73 (48.0) | 79 (52.0) | 4.883 | .027* | 81 (53.3) | 71 (46.7) | 5.232 | .022* | | >4 cm | 29 (33.3) | 58 (66.7) | 33 (37.9) | 54 (62.1) |
| | Histological type | | Squamous cell carcinoma | 51 (40.8) | 74 (59.2) | 3.296 | .348 | 62 (49.6) | 63 (50.4) | 2.084 | .555 | | Adenocarcinoma | 25 (54.3) | 21 (45.7) | 23 (50.0) | 23 (50.0) | | Adenosquamous carcinoma | 24 (38.1) | 39 (61.9) | 28 (44.4) | 35 (55.6) | | Others | 2 (40.0) | 3 (60.0) | 1 (20.0) | 4 (80.0) |
| | Differentiation | | Well | 14 (87.5) | 2 (12.5) | 18.339 | <.001* | 14 (87.5) | 2 (12.5) | 18.479 | <.001* | | Moderate | 70 (43.7) | 90 (56.3) | 81 (50.6) | 79 (49.4) | | Poor | 18 (28.6) | 45 (71.4) | 19 (30.2) | 44 (69.8) |
| | Stage grouping with TNM | | Stage I | 64 (52.5) | 58 (47.5) | 10.055 | .007* | 70 (57.4) | 52 (42.6) | 9.693 | .008* | | Stage II | 58 (30.0) | 42 (70.0) | 21 (35.0) | 39 (65.0) | | Stage III-IV | 20 (42.7) | 37 (57.3) | 23 (40.4) | 34 (59.6) |
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