The Prognostic Significance of Beta2 Microglobulin in Patients with Hemophagocytic Lymphohistiocytosis
Table 2
Univariate and multivariate analysis of factors associated with OS in patients with HLH.
Covariate
OS
HR
95% CI
value
Univariate analysis
Age, y
<40 versus ≥40
1.164
0.639–2.120
0.620
WBC (×109/L)
<4 versus ≥4
0.518
0.248–1.082
0.080
Hb (g/L)
<90 versus ≥90
0.722
0.381–1.367
0.317
PLT (×109/L)
<40 versus ≥40
0.512
0.270–0.970
0.040
TG (mmol/L)
<3 versus ≥3
1.726
0.938–3.177
0.080
Fib (g/L)
<1.5 versus ≥1.5
0.791
0.435–1.441
0.444
Ferritin (ng/mL)
<6000 versus ≥6000
1.673
0.912–3.072
0.097
ALT (U/L)
<40 versus ≥40
1.129
0.613–2.081
0.697
AST (U/L)
<40 versus ≥40
1.184
0.617–2.270
0.611
ALB (g/L)
<30 versus ≥30
0.507
0.270–0.951
0.034
LDH (U/L)
<1000 versus ≥1000
1.902
1.043–3.470
0.036
-m (mg/L)
<4.03 versus ≥4.03
2.306
1.237–4.298
0.009
Multivariate analysis
PLT (×109/L)
<40 versus ≥40
0.502
0.262–0.959
0.037
ALB (g/L)
<30 versus ≥30
0.739
0.347–1.572
0.432
LDH (U/L)
<1000 versus ≥1000
1.309
0.643–2.664
0.458
β2-m (mg/L)
<4.03 versus ≥4.03
2.129
1.076–4.213
0.030
Lymphoma
(+) versus (−)
0.850
0.434–1.666
0.636
WBC, white blood cell; Hb, hemoglobin; PLT, platelet; TG, triglyceride; Fib, fibrinogen; ALT, alanine aminotransferase; AST, aspartate aminotransferase; ALB, albumin; LDH, lactic dehydrogenase; and -m, beta2 microglobulin. The detection limit of ferritin was 15000 ng/mL; patients with ferritin concentrations higher than this upper limit were assigned a value of 15000 ng/mL for univariate and multivariate analyses.
