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Disease Markers
Volume 2016 (2016), Article ID 1549063, 6 pages
http://dx.doi.org/10.1155/2016/1549063
Research Article

Serum Galectin and Renal Dysfunction in ST-Segment Elevation Myocardial Infarction

1Federal State Budgetary Institution “Research Institute for Complex Issues of Cardiovascular Diseases”, 6 Sosnovy Boulevard, Kemerovo 650002, Russia
2Federal State Budget Educational Institution of Higher Professional Education “Kemerovo State Medical Academy of the Ministry of Health of the Russian Federation”, 22a Voroshilov Street, Kemerovo 650029, Russia

Received 20 October 2015; Revised 10 January 2016; Accepted 19 January 2016

Academic Editor: Mariann Harangi

Copyright © 2016 Victoria Karetnikova et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

This study aimed to evaluate the association between serum galectin levels and renal dysfunction in relation to in-hospital prognosis and unfavorable prognosis 1 year after ST-elevated myocardial infarction (STEMI). Patients were assigned to two groups according to the cystatin C-based estimate of GFR on day 12 after STEMI: (1) STEMI patients with normal renal function (GFR based on cystatin C levels = 60 mL/min/1.73 m2) and (2) those with renal dysfunction (RD) (GFR based on cystatin C levels <60 mL/min/1.73 m2). A decrease in GFR estimated from the CKD-EPI equation on day 12 was more frequently found in patients with a reduced GFR based on cystatin C levels (41.9%) compared with those without RD (21.3%). Galectin levels exceeded the cut-off value (17.8 ng/mL) in 50.6% of cases in the group with GFR <60 mL/min/1.73 m2 and in 32% of cases in the group with a normal GFR. The presence of RD and elevated galectin levels >17.8 ng/mL on day 12 after MI are independent predictors of an adverse prognosis at 1 year in STEMI patients. Elevated galectin levels are directly correlated with the presence of early postinfarction angina.