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Disease Markers
Volume 2016 (2016), Article ID 1628041, 8 pages
Research Article

Two tagSNPs rs352493 and rs3760908 within SIRT6 Gene Are Associated with the Severity of Coronary Artery Disease in a Chinese Han Population

1Institute of Aging Research, Guangdong Medical University, Dongguan 523808, China
2Institute of Biochemistry & Molecular Biology, Guangdong Medical University, Zhanjiang 524023, China
3Key Laboratory for Medical Molecular Diagnostics of Guangdong Province, Guangdong Medical University, Dongguan 523808, China
4Department of Cardiovascular Disease, The First People’s Hospital of Foshan, Foshan 528000, China
5Department of Cardiovascular Disease, The Affiliated Hospital of Guangdong Medical University, Zhanjiang 524023, China

Received 6 December 2015; Revised 22 February 2016; Accepted 7 March 2016

Academic Editor: Yi-Chia Huang

Copyright © 2016 Sai-sai Tang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


SIRT6 has been demonstrated to exert protective effects on endothelial cells and is closely associated with lipid metabolism, glucose metabolism, and obesity, indicating an important role in the pathogenesis and progression of coronary artery disease (CAD). Nonetheless, the biological significance of SIRT6 variants on CAD is far to be elucidated. Here we aimed to investigate the influence of SIRT6 polymorphisms on individual susceptibility and severity of CAD. Multivariate logistic regression analysis exhibited no significant association between these five polymorphisms and CAD risk in the genotype and allele frequencies. However, we found that the rs352493 polymorphism in SIRT6 exhibited a significant effect on the severity of CAD; C allele (χ2 = 7.793, adjusted ) and the combined CC/CT genotypes (χ2 = 5.609, adjusted ) presented the greater CAD severity. In addition, A allele (χ2 = 5.208, adjusted ) and AA (χ2 = 4.842, adjusted ) of rs3760908 were also associated with greater CAD severity in Chinese subjects. Our data provided the first evidence that SIRT6 tagSNPs rs352493 and rs3760908 play significant roles in the severity of CAD in Chinese Han subjects, which might be useful predictors of the severity of CAD.