Two tagSNPs rs352493 and rs3760908 within SIRT6 Gene Are Associated with the Severity of Coronary Artery Disease in a Chinese Han Population

Table 3

Multivariate associations of tagSNPs in SIRT6 gene with the risk of CAD.

Type	Controls ()	Cases ()	OR (95% CI)
	Number (%)	Number (%)
rs11878868
Additive
G	1183 (90.3)	856 (90.3)	1
T	127 (9.7)	92 (9.7)	0.97 (0.69–1.36)	0.870
Dominant
GT + GG	647 (98.8)	471 (99.4)	1
TT	8 (1.2)	3 (0.6)	0.60 (0.14–2.57)	0.487
Recessive
GG	536 (81.8)	385 (81.2)	1
GT + TT	119 (18.2)	89 (18.8)	1.00 (0.69–1.45)	0.993
rs107251
Additive
T	388 (29.6)	279 (29.4)	1
C	922 (70.4)	669 (70.6)	1.13 (0.90–1.41)	0.293
Dominant
TT	59 (9.0)	37 (7.8)	1
CC + CT	596 (91.0)	437 (92.2)	1.65 (0.98–2.76)	0.060
Recessive
CT + TT	329 (50.2)	242 (51.1)	1
CC	326 (49.8)	232 (48.9)	1.04 (0.78–1.39)	0.774
rs352493
Additive
T	977 (74.6)	721 (76.1)	1
C	333 (25.4)	227 (23.9)	0.99 (0.78–1.25)	0.921
Dominant
CC	41 (6.3)	30 (6.3)	1
CT + TT	614 (93.7)	444 (93.7)	0.98 (0.54–1.78)	0.944
Recessive
CT + CC	292 (44.6)	197 (41.6)	1
TT	363 (55.4)	277 (58.4)	0.99 (0.74–1.32)	0.929
rs4807546
Additive
C	478 (36.5)	352 (37.1)	1
T	832 (63.5)	596 (62.9)	0.94 (0.76–1.16)	0.565
Dominant
TT	263 (40.2)	189 (39.9)	1
CT + CC	392 (59.8)	285 (60.1)	0.96 (0.72–1.28)	0.763
Recessive
CT + TT	569 (86.9)	407 (85.9)	1
CC	86 (13.1)	67 (14.1)	0.86 (0.57–1.30)	0.478
rs3760908
Additive
G	741 (56.6)	562 (59.3)	1
A	569 (43.4)	386 (40.7)	0.95 (0.77–1.17)	0.616
Dominant
AA	113 (17.3)	86 (18.1)	1
AG + GG	542 (82.7)	388 (81.9)	0.88 (0.60–1.29)	0.506
Recessive
GG	199 (30.4)	174 (36.7)	1
AG + AA	456 (69.6)	300 (63.3)	0.83 (0.61–1.12)	0.212

Adjusted for age, sex, smoking, drinking, hypertension, diabetes, and hyperlipidemia.