Overexpression of Prolyl-4-Hydroxylase-α1 Stabilizes but Increases Shear Stress-Induced Atherosclerotic Plaque in Apolipoprotein E-Deficient Mice

Figure 1

Effect of P4Ha1 overexpression on plaque size and the efficiency of lentivirus-P4Ha1 in mice. (a) Cross sections of carotid arteries stained with hematoxylin and eosin. (b) Analyses of plaque area. (c) RT-PCR analysis of P4Ha1 mRNA expression with lenti-P4Ha1, lenti-EGFP, and mock treatment. (d) Western blot analysis of P4Ha1 protein expression with lenti-P4Ha1, lenti-EGFP, and mock treatment ( versus mock; versus lenti-EGFP).

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