Identification of Gingival Crevicular Fluid Sampling, Analytical Methods, and Oral Biomarkers for the Diagnosis and Monitoring of Periodontal Diseases: A Systematic Review
Table 1
Summary of washing techniques used in the GCF collection.
To evaluate inflammatory activity in GCF in RA patients and patients without RA. To determine if the periodontal inflammation reduced after RA treatment.
RA anti-inflammatory treatment reduced periodontal inflammation.
Capillary zone electrophoresis coupled with laser induced fluorescence detection (CZE-LIFD)
Arginine, glutamate
To evaluate the glutamate and arginine GCF levels in adult chronic periodontitis (CP) patients against healthy controls. To compare two types of microdialysis probes: U-shaped probes and normal.
Arginine level was elevated and glutamate level was decreased in CP patients, compared to healthy subjects. No statistical differences were found between the U-shaped and normal probes.