Identification of Gingival Crevicular Fluid Sampling, Analytical Methods, and Oral Biomarkers for the Diagnosis and Monitoring of Periodontal Diseases: A Systematic Review

Table 8

Comparison of the mean of MMP-8 concentration between different studies using the same analytical techniques.

Study	[67]	[88]
ELISA kit	Standard ELISA kit	Standard ELISA kit
	(Quantikine R & D Systems)	(Quantikine R & D Systems)
GCF collection method	Paper strips	Paper strips
Number of subjects	21H, 30CP	10H, 10CP
Number of samples	1	1
Mean and SD for MMP-8 concentration (pg/ml) and clinical parameters for CP patients	18.6 (6.4)	15.13 (12.46)
	PD = 6.4 (0.6)	PD = 6.9 (1.9)
	CAL = 5.4 (0.9)	CAL = 5.5 (1.3)
	PI (%) = 64.4 (18.8)	BOP (%) = 57.9 (14.6)
	GI = 2.3 (0.8)
Mean and SD for MMP-8 concentration (pg/ml) and clinical parameters for H subjects	2.6 (2.6)	4.13 (12.32)
	PD = 1.5 (0.9)	PD = 2.5 (1.9)
	CAL ≤ 1	CAL = 1.9 (0.5)
	PI (%) = 45.8 (12.7)	BOP (%) = 5.32 (3.71)
	GI = 0.7 (0.3)