Predictive Value of Plasma MicroRNA-216a/b in the Diagnosis of Esophageal Squamous Cell Carcinoma

Table 1

Clinicopathologicalcharacteristics of patients with ESCC.

Characteristics	(%)	Plasma miRNA-718 expression (mean ± SD)
		miR-216a	value	miR-216b	value
Age (year)			0.1082		0.2125
≤63	46 (38.3)	0.058 ± 0.048		0.079 ± 0.086
>63	74 (61.7)	0.074 ± 0.054		0.099 ± 0.087
Gender			0.5388		0.5912
Male	79 (65.8)	0.070 ± 0.055		0.094 ± 0.087
Female	41 (34.2)	0.064 ± 0.048		0.085 ± 0.089
Smoking			0.1342		0.6168
Never	52 (43.3)	0.060 ± 0.047		0.087 ± 0.079
Ever	68 (56.7)	0.074 ± 0.056		0.095 ± 0.093
Alcohol use			0.2378		0.5386
Never	40 (33.3)	0.060 ± 0.054		0.098 ± 0.087
Ever	80 (66.7)	0.072 ± 0.051		0.088 ± 0.087
Tumor location			0.3136		0.1810
Upper esophagus	11 (9.2)	0.065 ± 0.061		0.106 ± 0.092
Middle esophagus	70 (58.3)	0.074 ± 0.056		0.100 ± 0.096
Low esophagus	39 (32.5)	0.058 ± 0.041		0.072 ± 0.066
Histologic grade			0.8959		0.8308
Well differentiated	33 (27.5)	0.070 ± 0.059		0.109 ± 0.112
Moderately differentiated	70 (58.3)	0.068 ± 0.052		0.089 ± 0.082
Poorly differentiated	17 (14.2)	0.063 ± 0.040		0.068 ± 0.030
T stage			0.3206		0.6600
Tis-T1	36 (30.0)	0.075 ± 0.061		0.115 ± 0.114
T2	28 (23.3)	0.086 ± 0.065		0.100 ± 0.090
T3	41 (34.2)	0.056 ± 0.037		0.074 ± 0.065
T4	15 (12.5)	0.050 ± 0.019		0.067 ± 0.031
Lymph node metastasis			0.0845		0.0168
Negative	42 (35.0)	0.088 ± 0.068		0.134 ± 0.117
Positive	78 (65.0)	0.057 ± 0.038		0.068 ± 0.054
TNM stage			0.0054		0.0359
0-I	29 (24.2)	0.088 ± 0.062		0.134 ± 0.119
II	28 (23.3)	0.086 ± 0.065		0.101 ± 0.090
III	40 (33.3)	0.058 ± 0.035		0.072 ± 0.067
IV	23 (19.2)	0.039 ± 0.022		0.060 ± 0.029