Urinary Lysosomal Enzyme Activities and Albuminuria in Ghanaian Patients with Type 2 Diabetes Mellitus
Table 1
Clinical and biochemical parameters of the study population.
Parameters
Diabetics ()
Controls ()
value
Age (yrs)
55.3 ± 11.7
51.2 ± 11.5
0.061
SBP (mmHg)
147.8 ± 28.3
145.4 ± 21.8
0.388
DBP (mmHg)
88.8 ± 15.2
84.6 ± 10.6
0.079
BMI (kg/m2)
28.6 ± 4.7
26.2 ± 2.6
0.001
WHR (ratio)
0.88 ± 0.17
0.81 ± 0.11
0.230
FBG (mmol/L)
9.68 ± 3.4
5.8 ± 1.2
0.001
T.CHOL (mmol/L)
5.87 ± 1.1
4.88 ± 1.0
0.018
TG (mmol/L)
1.99 ± 0.7
1.60 ± 0.6
0.006
HDL (mmol/L)
1.58 ± 0.6
1.89 ± 0.7
0.006
LDL (mmol/L)
3.32 ± 0.9
2.63 ± 1.3
0.004
S-creatinine (µmol/L)
98.8 ± 15.0
85.4 ± 10.9
0.001
eGFR (mL/min)
77.8 ± 10.8
93.6 ± 11.3
0.001
Period of diabetes (yrs)
8.2 ± 6.1
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Urinary biochemical analytes of the study population
U-creatinine (g/L)
2.1 ± 1.5
1.1 ± 0.8
0.001
U-albumin (mg/L)
46.1 ± 13.4
35.1 ± 12.8
0.092
NAG (U/L)
13.0 ± 2.2
10.1 ± 1.3
0.001
AAP (mg/L)
4.35 ± 1.3
3.89 ± 0.9
0.024
U-Alb/U-Cr (mg/g)
54.1 ± 14.9
17.8 ± 12.6
0.001
NAG/U-Cr (U/g)
17.9 ± 8.0
9.8 ± 5.4
0.001
AAP/U-Cr (ng/g)
5.74 ± 3.6
3.0 ± 2.4
0.001
Values are given as mean ± standard deviation. : mean difference is significant. : mean difference is highly significant. SBP is systolic blood pressure, DBP is diastolic blood pressure, WHR is waist hip ratio, T.CHOL is total cholesterol, TG is triglyceride, HDL is high density lipoprotein, LDL is low density lipoprotein, FBG is fasting blood glucose, BMI is body mass index, eGFR is estimated glomerular filtration rate, NAG is N-acetyl--D-glucosaminidase, and AAP is alanine aminopeptidase. U-Cr is urinary creatinine and U-Alb is urinary albumin.
