Research Article

Identification of Differentially Expressed Kinase and Screening Potential Anticancer Drugs in Papillary Thyroid Carcinoma

Table 1

The functions of the most discussed protein kinases involved in PTC.

FunctionKinases

Protein amino acid phosphorylationEGFR, MAPK1, MEK, MEKK, MEKKK, CDKL1, PDGFRA, FGFR2, ERBB4, ERBB3, SRC, TGFBR1, MET, ATM, CSK, LYN, CDK9, CDK6, CDK7, LCK, HCK, FLT4, FYN, JAK3
PhosphorylationBTK, MEKKK, MEKK, EGFR, MAPK1, PDGFRA, FGFR2, ERBB4, ERBB3, EPHB1, SRC, TGFBR1, MET, ATM, CSK, CDK6, LCK, HCK
Phosphorus metabolic processBTK, MEK, MEKK, EGFR, MAPK1 PDGFRA, FGFR2, ERBB4, ERBB3, EPHB1, SRC, TGFBR1, MET, ATM, CSK, LYN, CDK6, LCK, FYN, JAK3
Phosphate metabolic processBTK, MEKK, MEK, EGFR, MAPK, PDGFRA, FGFR2, FGR, ERBB4, ERBB3, EPHB1, SRC, TGFBR1, MET, ATM, NTRK3, NTRK2, DYRK1A, CSK, LYN, CDK9, CDK6, CDK7, LCK, HCK, FYN JAK3
Protein kinase cascadeERBB3, SRC, BTK, MEKK, MEK, EGFR, TGFBR1, MET, MAPK, FYN, JAK3
Intracellular signaling cascadeBTK, MEKK, CSK, MEK, EGFR, LYN, CDK, MEKKK, MAPK1, ERBB3, SRC, TGFBR1, MET, ATM, FYN, JAK3
Protein amino acid autophosphorylationEGFR, TGFBR1, MET, MEKK, FYN, PDGFRA
Enzyme linked receptor protein signaling pathwayFGFR2, ERBB4, ERBB3, SRC, EPHB1, MEKK, AKT2, EGFR, TGFBR1, MET PDGFRA, JAK3
Transmembrane receptor protein tyrosine kinase signaling pathwayEGFR, FGFR2, ERBB4, ERBB3, MET, SRC, EPHB1, PDGFRA, AKT2
Peptidyl-tyrosine phosphorylationERBB4, LYN, ERBB3, FYN, PDGFRA, JAK3, SRC, BTK
MAPKKK cascadeEGFR, MEK, TGFBR1, MET, MAPK, MEKK
Peptidyl-tyrosine modificationERBB4, LYN, ERBB3, FYN, PDGFRA, JAK3, SRC, BTK
Regulation of phosphorylationEGFR, MEK, LYN, TGFBR1, MET, CDK7, MEKK
Regulation of transferase activityEGFR, MEK, TGFBR1, MET, CDK7, MEKK
Regulation of phosphate metabolic processEGFR, MEK, LYN, TGFBR1, MET, CDK, MEKK
Regulation of phosphorus metabolic processEGFR, MEK, LYN, TGFBR1, MET, CDK, MEKK
Regulation of protein kinase activityEGFR, MAP2K1, TGFBR1, MET, CDK7, MAP3K5, MAP3K1, MAP2K6
Regulation of kinase activityEGFR, MAP2K1, TGFBR1, MET, CDK7, MAP3K5, MAP3K1, MAP2K6
Regulation of cell motionEGFR, LYN, MAP2K1, ERBB4, TGFBR1, MAPK1, MAP3K1, PDGFRA,
Positive regulation of cell motionEGFR, MAPK1, ERBB4, MAP2K1, LYN, TGFBR1, PDGFRA,
Regulation of cell migrationEGFR, MAPK1, ERBB4, MAP2K1, MAP3K1, PDGFRA,
Cell surface receptor linked signal transductionFGFR2, ERBB4, ERBB3, SRC, EPHB1, MAP3K1, TEK, EGFR, LYN, TGFBR1, MET, MAPK1, FYN, MAPK14, LCK, PDGFRA, JAK3
Regulation of locomotionEGFR, MAPK1, ERBB4, MAP2K1, MAP3K1, PDGFRA
Response to hormone stimulusERBB4, MAP2K1, LYN, ERBB3, TGFBR1, SRC, MAPK1, PDGFRA
Regulation of MAP kinase activityEGFR, MAP3K5, MAP2K1, MAP3K1, MET, MAP2K6
Positive regulation of cell communicationEGFR, LYN, ERBB4, ERBB3, TGFBR1, SRC, MAP3K3, LCK
Regulation of cell proliferationEGFR, FGFR2, ERBB4, LYN, ERBB3, TGFBR1, CDK6, MAPK1, PDGFRA, CSK, MAP2K5
Response to organic substanceEGFR, ERBB4, MAP2K1, LYN, ERBB3, TGFBR1, SRC, MAPK1, FYN, MAPK14, PDGFRA
Response to endogenous stimulusERBB4, MAP2K1, LYN, ERBB3, TGFBR1, SRC, MAPK1, PDGFRA
Positive regulation of cell proliferationEGFR, FGFR2, ERBB4, LYN, TGFBR1, CDK6, MAPK1, PDGFRA, MAP2K5
Positive regulation of cell migrationEGFR, MAPK1, ERBB4, MAP2K1, PDGFRA,
JNK cascadeMAP3K5, MAP3K1, MAP2K4, MAP3K12
Stress-activated protein kinase signaling pathwayMAP3K5, MAP3K1, MAP2K4, MAP3K12
Positive regulation of protein kinase activityEGFR, MAP3K5, MAP2K1, MAP3K1, TGFBR1, MET, MAP2K6
Positive regulation of locomotionEGFR, MAPK1, ERBB4, MAP2K1, PDGFRA
Positive regulation of kinase activityEGFR, MAP3K5, MAP2K1, MAP3K1, TGFBR1, MET, MAP2K6
Positive regulation of MAP kinase activityEGFR, MAP3K5, MAP2K1, MAP3K1, MET, MAP2K6
Positive regulation of transferase activityEGFR, MAP3K5, MAP2K1, MAP3K1, TGFBR1, MET, MAP2K6