Proteomic Biomarkers Panel: New Insights in Chronic Kidney Disease

Table 4

Correlations between inflammatory cytokines, bone and mineral disorder biomarkers, and eGFR in patients with CKD stages 2–4, not undergoing dialysis.

	⁢IL-6			TNF-α			OPN			OPG			OCN			FGF-23			Fetuin-A
	<6	≥6		<5	≥5		<6000	≥6000		<400	≥400		<12000	≥12000		<35	≥35		<400	≥400
Gender
M	31	31	= 0.16	39	23	= 0.29	13	49	= 0.65	10	52	= 0.17	21	41	= 0.75	20	42	= 0.29	13	49	= 0.65
F	8	16		18	6		4	20		7	17		9	15		5	19		4	20
Age
<60	10	12	= 0.99	12	10	= 0.18	7	15	= 0.09	7	15	= 0.09	9	13	= 0.5	4	18	= 0.19	7	15	= 0.09
≥60	29	35		45	19		10	54		10	54		21	43		21	43		10	54
eGFR
<60	27	47	< 0.001	46	28	= 0.04	12	62	= 0.04	14	60	= 0.6	22	52	= 0.01	15	59	< 0.001	17	64	= 0.07
≥60	12	0		11	1		5	7		3	9		8	4		10	2		0	12
IL-6
<6				32	7	< 0.005	12	27	< 0.02	13	26	= 0.004	18	21	= 0.04	16	23	= 0.02	7	32	= 0.7
≥6				25	22		5	42		4	43		12	35		9	38		10	37
TNF-α
<5							19	38	= 0.03	15	42	= 0.03	22	35	= 0.3	22	35	= 0.006	7	50	= 0.01
≥5							3	26		2	27		8	21		3	26		10	19
OPN
<6000										6	11	= 0.07	10	7	= 0.02	6	11	= 0.52	3	14	= 0.8
≥6000										11	58		20	49		19	50		14	55
OPG
<400													9	8	= 0.08	4	13	= 0.57	4	13	= 0.66
≥400													21	48		21	48		13	56
OCN
																14	16	= 0.008	6	24	= 0.96
																11	45		11	45
FGF-23
<35																			2	23	= 0.07
≥35																			15	46
Fetuin-A
<400
≥400