WISP1 Is Increased in Intestinal Mucosa and Contributes to Inflammatory Cascades in Inflammatory Bowel Disease

Figure 5

Treatment of rWISP1 aggravates TNBS-induced colitis in vivo. (a) BALB/c mice were TNBS colitis induced as indicated. rWISP1 or control medium intraperitoneally daily starting at the beginning of the TNBS induction till the end of the model was administered to two groups of TNBS-induced mice. rWISP1 or control medium as indicated above was administered to two groups of non-TNBS-treated mice. The changes in body weight during the whole colitis model are expressed as a percentage of the original weight at the start of the experiments. (b) Representative morphology of the intestine on day 7 after TNBS treatment. (c) Representative H&E staining of the colons (original magnification ×200). (d) Pathological scores were evaluated during the whole colitis model. Student’s -test was performed. ; data are expressed as mean ± s.e.m. for all samples.

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