Interplay between Matrix Metalloproteinase-9, Matrix Metalloproteinase-2, and Interleukins in Multiple Sclerosis Patients

Figure 2

Median of serum and CSF IL-17, IL-18, IL-23, and MCP-3 concentrations in RRMS patients and OND controls. None of the examined cytokines/chemokines was different between RRMS patients and OND patients in either the serum or CSF. (a) Serum levels of IL-17 in RRMS (median (IQR): 33.7 (4.2–335.0) pg/mL) and OND (44.8 (4.1–468.0) pg/mL) patients. (b) Serum levels of IL-18 in RRMS (2259 (1232–3505) pg/mL) and OND (2266 (1509–3766) pg/mL) patients. (c) Serum levels of IL-23 in RRMS (212.3 (64.9–625.3) pg/mL) and OND (148.9 (54.6–774.9) pg/mL) patients. (d) Serum levels of MCP-3 in RRMS (6.3 (2.6–18.4) pg/mL) and OND (7.5 (3.5–14.7) pg/mL) patients. (e) CSF levels of IL-17 in RRMS (7.0 (2.0–11.1) pg/mL) and OND (7.1 (2.3–16.1) pg/mL) patients. (f) CSF levels of IL-18 in RRMS (218 (49–551) pg/mL) and OND (269 (71–644) pg/mL) patients. (g) CSF levels of IL-23 in RRMS (13.4 (5.9–65.9) pg/mL) and OND (18.2 (11.4–57.1) pg/mL) patients. (h) CSF levels of MCP-3 in RRMS (2.6 (1.5–7.8) pg/mL) and OND (4.3 (1.3–9.1) pg/mL) patients. IQR: interquartile range; CSF: cerebrospinal fluid; IL: interleukin; MCP: Monocyte Chemoattractant Protein; RRMS: relapsing-remitting MS; OND: other neurological disorders.

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