Interplay between Matrix Metalloproteinase-9, Matrix Metalloproteinase-2, and Interleukins in Multiple Sclerosis Patients

Table 4

Percentage of MS patients and OND controls with abnormal serum and CSF values.

	OND (%)	MS (%)
Serum
High active MMP-9	46.7	53.9
Low active MMP-2	53.3	49.4
High IL-17	8.7	12.4
High IL-18	43.5	42.7
High IL-23	32.6	38.2
High MCP-3	30.4	30.3
Combined interleukins	63.0	69.7
CSF
High active MMP-9	40.2	62.9
Low active MMP-2	51.8	47.6
High IL-17	20.7	13.5
High IL-18	28.3	30.3
High IL-23	9.8	9.0
High MCP-3	28.3	24.7
Combined interleukins	45.7	44.9

The cut-off values used for the determination of the frequency of abnormal values were as follows.
Serum: active MMP-9, 534 ng/mL; active MMP-2, 25.2 ng/mL; IL-17, 33.6 pg/mL; IL-18, 2262 pg/mL; IL-23, 181 pg/mL; MCP-3, 7.2 pg/mL.
CSF: active MMP-9, 0.055 ng/mL; active MMP-2, 5.06 ng/mL; IL-17, 7 pg/mL; IL-18, 237 pg/mL; IL-23, 15.9 pg/mL; MCP-3, 3 pg/mL.
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