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Disease Markers
Volume 2016 (2016), Article ID 3970284, 7 pages
http://dx.doi.org/10.1155/2016/3970284
Research Article

Serum NT-proBNP Levels Are Not Related to Vitamin D Status in Young Patients with Congenital Heart Defects

1Endocrinology Unit, IRCCS Policlinico San Donato, 20097 San Donato Milanese, Italy
2Laboratorio di Chimica Clinica, IRCCS Policlinico San Donato, 20097 San Donato Milanese, Italy
3Laboratory of Molecular Biology, IRCCS Policlinico San Donato, 20097 San Donato Milanese, Italy
4Pediatric Cardiosurgery, IRCCS Policlinico San Donato, 20097 San Donato Milanese, Italy
5Endocrinology Unit, Department of Biomedical Sciences for Health, University of Milan, IRCCS Policlinico San Donato, 20097 San Donato Milanese, Italy

Received 30 August 2015; Revised 1 November 2015; Accepted 4 November 2015

Academic Editor: Yi-Chia Huang

Copyright © 2016 E. Passeri et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Context. Hypovitaminosis D frequently occurs in early life and increases with age. Vitamin D has been suggested to influence cardiac performance and N-terminal-pro-type B natriuretic peptide (NT-proBNP) release in adults with heart failure. Objectives. To assess the vitamin D status and the impact of hypovitaminosis D on circulating NT-proBNP levels in young patients with congenital heart defects (CHD). Design and Patients. This cross-sectional study included the assessment of serum 25-hydroxyvitamin D (25OHD), parathyroid function markers, and NT-proBNP levels in a series of 230 young in-patients (117 females, 113 males; 6.4 (4.0–9.1) years (median, interquartile range)) with CHD. Results. Serum 25OHD levels <20 ng/mL were detected in 55.3% of patients. Optimal 25OHD levels (>30 ng/mL) occurred in 25% of patients. Serum 25OHD levels inversely correlated with age (, ) and height standard deviation score (, ). After correction for age, 25OHD negatively correlated with serum PTH levels (, ). PTH levels above the upper quartile (44 pg/mL) occurred in 32% of hypovitaminosis D patients. Serum NT-proBNP levels were not correlated with 25OHD and PTH levels. Conclusions. Half of the young CHD patients were diagnosed with 25OHD deficiency and a third of hypovitaminosis D patients experienced hyperparathyroidism. Nonetheless, serum NT-proBNP levels were not associated with hypovitaminosis D as well as hyperparathyroidism.