Plasma Cathepsin S and Cathepsin S/Cystatin C Ratios Are Potential Biomarkers for COPD

Figure 2

ROC curves for cathepsin S (a), cystatin C (b), and cathepsin S/cystatin C (c). AUC was 0.831, 0.806, and 0.710, respectively. Dotted arrows indicate the best cutpoints for both sensitivity and specificity. Better sensitivities (98% and 97%, resp.) were obtained when the cut points were set at cathepsin S 12.1 ng/mL and cathepsin S/cystatin , indicated by the solid arrows in (a) and (c), and the specificities were 62% and 55%, respectively.

(a)

(b)

(c)