Research Article
Plasma Cathepsin S and Cathepsin S/Cystatin C Ratios Are Potential Biomarkers for COPD
Table 3
Logistic regression analysis for severe airflow limitation (% FEV1 predicted < 50).
| | Cathepsin S and % FEV1predicted < 50 | Cat S/Cys C (/103) and % FEV1 predicted < 50 | | | | OR | 95% CI | | | OR | 95% CI |
| Cat S (10 increments) | 7.82 | | 0.32 | 0.14–0.71 | — | — | — | — | Cat S/Cys C (/103) | — | — | — | — | 5.19 | | 0.87 | 0.77–0.98 | Age (10 increments) | 12.14 | | 3.82 | 1.80–8.12 | 10.76 | | 3.02 | 1.56–5.84 | BMI | 2.28 | 0.13 | 0.90 | 0.79–1.03 | 2.77 | 0.10 | 0.89 | 0.77–1.02 | PY (10 increments) | 2.46 | 0.12 | 1.11 | 0.97–1.27 | 1.21 | 0.27 | 1.07 | 0.95–1.22 | Serum Cr | 5.05 | | 0.02 | 0.001–0.60 | 6.35 | | 0.014 | 0.0005–0.39 | Male | 3.35 | 0.07 | 11.93 | 0.84–169.5 | 4.10 | | 15.13 | 1.09–209.5 | Ex-smoker | 1.44 | 0.23 | 1.88 | 0.67–5.28 | 2.97 | 0.09 | 2.45 | 0.88–6.79 | HT (−) | 2.18 | 0.14 | 0.40 | 0.12–1.35 | 2.09 | 0.15 | 0.42 | 0.13–1.36 | ICS (−) | 0.001 | 0.97 | 1.03 | 0.26–4.07 | 0.044 | 0.83 | 0.87 | 0.23–3.23 |
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; . FEV1: forced expiratory volume in 1 second; Cat: cathepsin; Cys: cystatin; OR: odds ratio; CI: confidence interval; BMI: body mass index; PY: pack-years; Cr: creatinine; HT: hypertension; ICS: inhaled corticosteroid.
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