Plasma Cathepsin S and Cathepsin S/Cystatin C Ratios Are Potential Biomarkers for COPD

Table 4

Logistic regression analysis for significant emphysematous change (LAA 8.0).

	Cathepsin S and LAA 8.0				Cat S/Cys C (/10^3) and LAA 8.0
			OR	95% CI			OR	95% CI
Cat S (10 increments)	12.21		0.28	0.14–0.57	—	—	—	—
Cat S/Cys C (/10^3)	—	—	—	—	9.83		0.82	0.72–0.93
Age (10 increments)	5.72		2.08	1.14–3.78	3.76	0.052	1.72	0.99–2.98
BMI	3.45	0.06	0.87	0.75–1.01	4.36		0.85	0.73–0.99
PY (10 increments)	1.92	0.17	1.09	0.96–1.24	0.74	0.39	1.05	0.94–1.19
Serum Cr	0.37	0.54	0.40	0.02–7.71	1.55	0.21	0.16	0.009–2.88
Male	1.28	0.26	3.17	0.43–23.4	2.51	0.11	4.71	0.69–32.1
Ex-smoker	0.31	0.58	1.30	0.51–3.29	1.46	0.23	1.76	0.70–4.42
HT (−)	0.84	0.36	0.58	0.18–1.86	0.77	0.38	0.60	0.20–1.87
ICS (−)	0.07	0.79	0.85	0.25–2.89	0.21	0.65	0.76	0.23–2.51

; . LAA: low attenuation area; Cat: cathepsin; Cys: cystatin; OR: odds ratio; CI: confidence interval; BMI: body mass index; PY: pack-years; Cr: creatinine; HT: hypertension; ICS: inhaled corticosteroid.