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Disease Markers
Volume 2016 (2016), Article ID 4218989, 10 pages
http://dx.doi.org/10.1155/2016/4218989
Research Article

Expression of CAF-Related Proteins Is Associated with Histologic Grade of Breast Phyllodes Tumor

Department of Pathology, Yonsei University College of Medicine, Seoul, Republic of Korea

Received 18 September 2016; Accepted 10 October 2016

Academic Editor: Gad Rennert

Copyright © 2016 Hye Min Kim et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Purpose. The purpose of this study was to investigate the expression of cancer-associated fibroblast- (CAF-) related proteins and the implications in breast phyllodes tumor (PT). Methods. Tissue microarrays of 194 PT cases (151 benign PT, 27 borderline PT, and 16 malignant PT) were constructed. We performed immunohistochemical staining for CAF-related proteins (podoplanin, prolyl 4-hydroxylase, FAPα, S100A4, PDGFR α/β, and NG2) and analyzed the results according to clinicopathologic parameters. Results. Expression of PDGFRα and PDGFRβ in the stromal component increased with increasing histologic grade of PT ( and , resp.). Among clinicopathologic parameters, only expression of FAPα in stroma was associated with distant metastasis (). In univariate analysis, stromal expression of PDGFRα was associated with shorter overall survival (). In Cox multivariate analysis, stromal overgrowth and PDGFRα stromal positivity were associated with shorter overall survival ( and , resp.). Furthermore, expression of PDGFRβ in stroma was associated with shorter overall survival in patients with malignant PT (). Conclusion. Stromal expression of PDGFRα and PDGFRβ increased with increasing histologic grade of PT. In addition, PDGFR stromal positivity was associated with shorter overall survival. These results suggest that CAFs are associated with breast PT progression.