Research Article
Expression of CAF-Related Proteins Is Associated with Histologic Grade of Breast Phyllodes Tumor
Table 2
Clinicopathologic characteristics of patients with phyllodes tumor.
| | Parameters | Total = 196 (100%) | PT, benign = 153 (100%) | PT, borderline = 27 (100%) | PT, malignant = 16 (100%) | value |
| | Age (years, mean ± SD) | 40.1 ± 12.3 | 38.9 ± 12.2 | 42.3 ± 11.5 | 47.6 ± 12.9 | 0.017 | | Tumor size (cm, mean ± SD) | 4.0 ± 2.6 | 3.6 ± 2.1 | 4.3 ± 2.5 | 6.7 ± 4.6 | <0.001 | | Stromal cellularity | | | | | <0.001 | | Mild | 121 (61.7) | 120 (78.4) | 1 (3.7) | 0 (0.0) | | | Moderate | 63 (32.1) | 33 (21.6) | 23 (85.2) | 7 (43.8) | | | Marked | 12 (6.1) | 0 (0.0) | 3 (11.1) | 9 (56.2) | | | Stromal atypia | | | | | <0.001 | | Mild | 156 (79.6) | 151 (98.7) | 5 (18.5) | 0 (0.0) | | | Moderate | 30 (15.3) | 2 (1.3) | 20 (74.1) | 8 (50.0) | | | Marked | 10 (5.1) | 0 (0.0) | 2 (7.4) | 8 (50.0) | | | Stromal mitosis | | | | | <0.001 | | 0–4/10 HPFs | 154 (78.6) | 153 (100.0) | 1 (3.7) | 0 (0.0) | | | 5–9/10 HPFs | 31 (15.8) | 0 (0.0) | 26 (96.3) | 5 (31.2) | | | ≥10/10 HPFs | 11 (5.6) | 0 (0.0) | 0 (0.0) | 11 (68.8) | | | Stromal overgrowth | | | | | <0.001 | | Absent | 179 (91.3) | 153 (100.0) | 24 (88.9) | 2 (12.5) | | | Present | 17 (8.7) | 0 (0.0) | 3 (11.1) | 14 (87.5) | | | Tumor margin | | | | | <0.001 | | Circumscribed | 176 (89.8) | 150 (98.0) | 20 (74.1) | 6 (89.7) | | | Infiltrative | 20 (10.2) | 3 (2.0) | 7 (25.9) | 10 (62.5) | | | Tumor recurrence | 18 (9.2) | 5 (3.3) | 6 (22.2) | 7 (43.8) | <0.001 | | Distant metastasis | 8 (4.1) | 0 (0.0) | 1 (3.7) | 7 (43.8) | <0.001 |
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PT, phyllodes tumor; HPF, high-power fields.
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