|
| Nr. crt. | Biomarker | Roles |
|
| () | CFH
FHL-1
Complement factor 1 | (i) Inhibiting one of the three pathways that activate the complement C3
(ii) Facilitating progression and migration of cSCC cells [60–62] |
|
| () | Serpin A1 | (i) Coagulation
(ii) Inflammation
(iii) Turnover of extracellular matrix
(iv) Inhibiting natural killer cell activity
(v) Stimulating malignant cell proliferation but not normal skin cell proliferation
(vi) Antiapoptotic effect [63, 64] |
|
| () | APC | (i) Inducing the destruction of β-catenin
(ii) Having a role in microtubule assembly [65] |
|
| () | Phosphorylated AKT,
mTOR (Ser2448),
4EBP1 (Ser65),
70S6K1 (Thr421),
p70S6K1 (Thr421/Ser424),
S6 (Ser6) | (i) Influencing apoptosis, proliferation, inflammation, and differentiation [55] |
|
| () | S100A7 | (i) Role in metastasis [66–70] |
|
| () | Col7A1 | (i) Encoding the information for Col7 formation [71] |
|
| () | MMP-7 | (i) Maintaining homeostasis of many tissues including skin, by proteolysis of extracellular matrix [72–74] |
|
| () | Krt8
Krt18 | (i) Together they induce a higher rate of invasiveness in a cell population [75] |
|
| () | CD133 | (i) Proliferation
(ii) Differentiation [46, 76–81] |
|
| () | CYFRA 21-1 | (i) Component of structural proteins involved in epithelial intermediary filaments formation [82–88] |
|
| () | mtDNA | (i) Mitochondrial functions [89, 90] |
|
| () | Hsp70 | (i) it is presumed that it may help tumorous cells survive apoptosis and necrosis [91] |
|
| () | Plectin | (i) Cytolinker of plakins family which forms the links between filaments [92] |
|
| () | Cofilin-I | (i) Vulvar carcinogenesis
(ii) Tumor progression [93] |
|
| () | Galectin-7
wee1 | (i) Invasiveness
(ii) Poor tumor differentiation [94, 95] |
|
| () | EphB2 | (i) Determining proliferation, migration, and invasion [96] |
|
