Multiplatform Biomarker Discovery for Bladder Cancer Recurrence Diagnosis
Table 2
Biomarker measurements with the automated platform.
Marker
Calibration curve in assay diluent
Calibration curve in urine
LOD (urine)
Marker detection in samples
PTGS2
−
+
5 ng/mL
+
FGFR-3
+
+
1000 pg/mL
+
Uroplakin-3a
−
−
N/A
N/A
Vimentin
+
+
112.5 ng/mL
−
MYC
+
+
1.25 ng/mL
−
Tropomodulin-1
+
+
2.5 ng/mL
+
BIRC5
+
+
1000 pg/mL
+
Fibulin-3
+
−
25 ng/mL (assay diluent)
+
p53
+
+
10 ng/mL
−
MMP-9
+
+
666.7 pg/mL
+
IL-8
+
+
125 pg/mL
+
EN2
+
+
1.25 ng/mL
+
+: presence of calibration curve or marker detection in samples. −: absence of calibration curve or no marker detection in samples. N/A: not applicable; LOD: limit of detection.
