Table of Contents Author Guidelines Submit a Manuscript
Disease Markers
Volume 2016, Article ID 5628176, 8 pages
http://dx.doi.org/10.1155/2016/5628176
Research Article

Novel Use for DOG1 in Discriminating Breast Invasive Carcinoma from Noninvasive Breast Lesions

1Institute of Pathology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China
2Department of Obstetrics and Gynecology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China

Received 5 November 2015; Revised 27 January 2016; Accepted 8 February 2016

Academic Editor: Gad Rennert

Copyright © 2016 Henghui Cheng et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. R. B. West, C. L. Corless, X. Chen et al., “The novel marker, DOG1, is expressed ubiquitously in gastrointestinal stromal tumors irrespective of KIT or PDGFRA mutation status,” American Journal of Pathology, vol. 165, no. 1, pp. 107–113, 2004. View at Publisher · View at Google Scholar · View at Scopus
  2. A. Caputo, E. Caci, L. Ferrera et al., “TMEM16A, a membrane protein associated with calcium-dependent chloride channel activity,” Science, vol. 322, no. 5901, pp. 590–594, 2008. View at Publisher · View at Google Scholar · View at Scopus
  3. M. Katoh and M. Katoh, “FLJ10261 gene, located within the CCND1-EMS1 locus on human chromosome 11q13, encodes the eight-transmembrane protein homologous to C12orf3, C11orf25 and FLJ34272 gene products,” International Journal of Oncology, vol. 22, no. 6, pp. 1375–1381, 2003. View at Google Scholar · View at Scopus
  4. M. K. Kashyap, A. Marimuthu, C. J. H. Kishore et al., “Genomewide mRNA profiling of esophageal squamous cell carcinoma for identification of cancer biomarkers,” Cancer Biology and Therapy, vol. 8, no. 1, pp. 34–46, 2009. View at Google Scholar · View at Scopus
  5. Y. D. Yang, H. Cho, J. Y. Koo et al., “TMEM16A confers receptor-activated calcium-dependent chloride conductance,” Nature, vol. 455, no. 7217, pp. 1210–1215, 2008. View at Publisher · View at Google Scholar · View at Scopus
  6. B. C. Schroeder, T. Cheng, Y. N. Jan, and L. Y. Jan, “Expression cloning of TMEM16A as a calcium-activated chloride channel subunit,” Cell, vol. 134, no. 6, pp. 1019–1029, 2008. View at Publisher · View at Google Scholar · View at Scopus
  7. J. R. Parfitt, M. Rodriguez-Justo, R. Feakins, and M. R. Novelli, “Gastrointestinal Kaposi's sarcoma: CD117 expression and the potential for misdiagnosis as gastrointestinal stromal tumour,” Histopathology, vol. 52, no. 7, pp. 816–823, 2008. View at Publisher · View at Google Scholar · View at Scopus
  8. I. Espinosa, C.-H. Lee, M. K. Kim et al., “A novel monoclonal antibody against DOG1 is a sensitive and specific marker for gastrointestinal stromal tumors,” American Journal of Surgical Pathology, vol. 32, no. 2, pp. 210–218, 2008. View at Publisher · View at Google Scholar · View at Scopus
  9. M. Miettinen, Z.-F. Wang, and J. Lasota, “DOG1 antibody in the differential diagnosis of gastrointestinal stromal tumors: a study of 1840 cases,” The American Journal of Surgical Pathology, vol. 33, no. 9, pp. 1401–1408, 2009. View at Publisher · View at Google Scholar · View at Scopus
  10. S. P. Sah and W. G. McCluggage, “DOG1 immunoreactivity in uterine leiomyosarcomas,” Journal of Clinical Pathology, vol. 66, no. 1, pp. 40–43, 2013. View at Publisher · View at Google Scholar · View at Scopus
  11. N. A. C. S. Wong and G. Shelley-Fraser, “Specificity of DOG1 (K9 clone) and protein kinase C theta (clone 27) as immunohistochemical markers of gastrointestinal stromal tumour,” Histopathology, vol. 57, no. 2, pp. 250–258, 2010. View at Publisher · View at Google Scholar · View at Scopus
  12. J. Hemminger, W. L. Marsh, O. H. Iwenofu, and W. L. Frankel, “DOG1 (Clone K9) is seldom expressed and not useful in the evaluation of pancreatic neoplasms,” Applied Immunohistochemistry and Molecular Morphology, vol. 20, no. 4, pp. 397–401, 2012. View at Publisher · View at Google Scholar · View at Scopus
  13. P. J. Gomez-Pinilla, S. J. Gibbons, M. R. Bardsley et al., “Ano1 is a selective marker of interstitial cells of Cajal in the human and mouse gastrointestinal tract,” American Journal of Physiology—Gastrointestinal and Liver Physiology, vol. 296, no. 6, pp. G1370–G1381, 2009. View at Publisher · View at Google Scholar · View at Scopus
  14. C. Ardeleanu, D. Arsene, M. Hinescu et al., “Pancreatic expression of DOG1: a novel gastrointestinal stromal tumor (GIST) biomarker,” Applied Immunohistochemistry and Molecular Morphology, vol. 17, no. 5, pp. 413–418, 2009. View at Publisher · View at Google Scholar · View at Scopus
  15. N. A. C. S. Wong, “Gastrointestinal stromal tumours—an update for histopathologists,” Histopathology, vol. 59, no. 5, pp. 807–821, 2011. View at Publisher · View at Google Scholar · View at Scopus
  16. S. R. Lakhani, I. O. Ellis, S. J. Schnitt et al., WHO Classification of Tumors of the Breast, International Arctic Research Center, University of Alaska, Fairbanks, Alaska, 2012.
  17. T. Kara, E. Serinsoz, R. B. Arpaci et al., “Contribution of DOG1 expression to the diagnosis of gastrointestinal stromal tumors,” Pathology Research and Practice, vol. 209, no. 7, pp. 413–417, 2013. View at Publisher · View at Google Scholar · View at Scopus
  18. A. N. Kalof, D. Tam, B. Beatty, and K. Cooper, “Immunostaining patterns of myoepithelial cells in breast lesions: a comparison of CD10 and smooth muscle myosin heavy chain,” Journal of Clinical Pathology, vol. 57, no. 6, pp. 625–629, 2004. View at Publisher · View at Google Scholar · View at Scopus
  19. R. Dewar, O. Fadare, H. Gilmore, and A. M. Gown, “Best practices in diagnostic immunohistochemistry: myoepithelial markers in breast pathology,” Archives of Pathology and Laboratory Medicine, vol. 135, no. 4, pp. 422–429, 2011. View at Google Scholar · View at Scopus
  20. S. Moritani, R. Kushima, H. Sugihara, M. Bamba, T. K. Kobayashi, and T. Hattori, “Availability of CD10 immunohistochemistry as a marker of breast myoepithelial cells on paraffin sections,” Modern Pathology, vol. 15, no. 4, pp. 397–405, 2002. View at Publisher · View at Google Scholar · View at Scopus
  21. R. W. Werling, H. Hwang, H. Yaziji, and A. M. Gown, “Immunohistochemical distinction of invasive from noninvasive breast lesions: a comparative study of p63 versus calponin and smooth muscle myosin heavy chain,” American Journal of Surgical Pathology, vol. 27, no. 1, pp. 82–90, 2003. View at Publisher · View at Google Scholar · View at Scopus
  22. M. Barbareschi, L. Pecciarini, M. G. Cangi et al., “p63, a p53 homologue, is a selective nuclear marker of myoepithelial cells of the human breast,” American Journal of Surgical Pathology, vol. 25, no. 8, pp. 1054–1060, 2001. View at Publisher · View at Google Scholar · View at Scopus
  23. G. M. Tse, P.-H. Tan, B. Chaiwun et al., “p63 is useful in the diagnosis of mammary metaplastic carcinomas,” Pathology, vol. 38, no. 1, pp. 16–20, 2006. View at Publisher · View at Google Scholar · View at Scopus
  24. S. Dwarakanath, A. K. C. Lee, R. A. Delellis, M. L. Silverman, L. Frasca, and H. J. Wolfe, “S-100 protein positivity in breast carcinomas: a potential pitfall in diagnostic immunohistochemistry,” Human Pathology, vol. 18, no. 11, pp. 1144–1148, 1987. View at Publisher · View at Google Scholar · View at Scopus
  25. H. Yaziji, A. M. Gown, and N. Sneige, “Detection of stromal invasion in breast cancer: the myoepithelial markers,” Advances in Anatomic Pathology, vol. 7, no. 2, pp. 100–109, 2000. View at Publisher · View at Google Scholar · View at Scopus
  26. C.-H. Lee, C.-W. Liang, and I. Espinosa, “The utility of discovered on gastrointestinal stromal tumor 1 (DOG1) antibody in surgical pathology-the GIST of it,” Advances in Anatomic Pathology, vol. 17, no. 3, pp. 222–232, 2010. View at Publisher · View at Google Scholar · View at Scopus
  27. L. F. Lopes, R. B. West, L. M. Bacchi, M. van de Rijn, and C. E. Bacchi, “DOG1 for the diagnosis of gastrointestinal stromal tumor (GIST): comparison between 2 different antibodies,” Applied Immunohistochemistry and Molecular Morphology, vol. 18, no. 4, pp. 333–337, 2010. View at Publisher · View at Google Scholar · View at Scopus
  28. J. Chênevert, U. Duvvuri, S. Chiosea et al., “DOG1: a novel marker of salivary acinar and intercalated duct differentiation,” Modern Pathology, vol. 25, no. 7, pp. 919–929, 2012. View at Publisher · View at Google Scholar · View at Scopus
  29. J. Almaça, Y. Tian, F. Aldehni et al., “TMEM16 proteins produce volume-regulated chloride currents that are reduced in mice lacking TMEM16A,” The Journal of Biological Chemistry, vol. 284, no. 42, pp. 28571–28578, 2009. View at Publisher · View at Google Scholar · View at Scopus
  30. K. Kunzelmann, P. Kongsuphol, F. Aldehni et al., “Bestrophin and TMEM16-Ca2+ activated Cl channels with different functions,” Cell Calcium, vol. 46, no. 4, pp. 233–241, 2009. View at Publisher · View at Google Scholar · View at Scopus
  31. J. Ousingsawat, J. R. Martins, R. Schreiber et al., “Loss of TMEM16A causes a defect in epithelial Ca2+-dependent chloride transport,” The Journal of Biological Chemistry, vol. 284, no. 42, pp. 28698–28703, 2009. View at Google Scholar