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Disease Markers
Volume 2016, Article ID 5965782, 7 pages
http://dx.doi.org/10.1155/2016/5965782
Research Article

Handheld Capillary Blood Lactate Analyzer as an Accessible and Cost-Effective Prognostic Tool for the Assessment of Death and Heart Failure Occurrence during Long-Term Follow-Up

1Clinical Department of Cardiovascular Diseases, Multidisciplinary Tertiary Hospital, Medical University of Silesia, 10 Curie-Skłodowska Street, 41-800 Zabrze, Poland
2Internal Medicine Department, Pyskowice Municipal Hospital, 2 Szpitalna Street, 44-120 Pyskowice, Poland
32nd Department of Cardiology in Zabrze, Medical University of Silesia, Katowice, Poland

Received 12 October 2016; Revised 26 November 2016; Accepted 6 December 2016

Academic Editor: Ying Huang

Copyright © 2016 Grzegorz M. Kubiak et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Impact of tissue lactate accumulation on prognosis after acute myocardial infarction (AMI) is biased. The study aimed to assess the prognostic role of lactate concentration (LC) in patients with AMI during one year of follow-up. 145 consecutive patients admitted due to AMI were enrolled. The data on the frequency of endpoint occurrence (defined as I, death; II, heart failure (HF); and III, recurrent myocardial infarction (re-MI)) were collected. The patients were divided into group A (LC below the cut-off value) and group B (LC above the cut-off value) for the endpoints according to receiver operating characteristic (ROC) analysis. The cumulative survival rate was 99% in group I-A and 85% in group I-B (p = 0.0004, log-rank test). The HF-free survival rate was 95% in group II-A and 82% in group II-B (p = 0.0095, log-rank test). The re-MI-free survival rate did not differ between groups. A multivariate Cox analysis showed a statistically significant influence of LC on death [Hazard Ratio (HR): 1.41, 95% Confidence Interval (CI) (1.13–1.76), and p = 0.002] and HF [HR: 1.21, 95% CI (1.05–1.4), and p = 0.007] with no impact on re-MI occurrence. LC in capillary blood may be considered a useful prognostic marker of late-onset heart failure and death after AMI.