Lymphocyte Antigen 75 Polymorphisms Are Associated with Disease Susceptibility and Phenotype in Japanese Patients with Inflammatory Bowel Disease
Table 4
Genotype distributions of LY75 gene polymorphisms in CD, UC, and healthy subjects.
SNP number
Alleles (1>2)
Genotype
Genotype frequency, %
Model
Controls versus CD
Controls versus UC
CD
UC
Controls
OR (95% CI)
OR (95% CI)
()
()
()
1
G>A
AA/AG/GG
21.6/37.3/41.2
25.5/46.8/27.7
22.3/51.3/26.4
Recessive
0.908
1.000
1.04 (0.50–2.16)
0.523
1.000
0.84 (0.49–1.44)
(GG + AG versus AA)
2
C>T
TT/TC/CC
23.5/39.2/37.3
12.8/41.5/45.7
10.4/45.0/44.6
Recessive
0.009
0.045
2.65 (1.24–5.64)
0.530
1.000
1.26 (0.61–2.59)
(CC + TC versus TT)
3
C>A
AA/AC/CC
25.5/35.3/39.2
24.5/45.7/29.8
20.8/46.5/32.7
Recessive
0.457
1.000
0.77 (0.38–1.54)
0.460
1.000
0.81 (0.47–1.41)
(CC + AC versus AA)
4
C>T
TT/TC/CC
15.7/49.0/35.3
11.7/45.7/42.6
13.0/45.4/41.6
Recessive
0.608
1.000
1.24 (0.54–2.86)
0.743
1.000
0.89 (0.43–1.82)
(CC + TC versus TT)
5
C>T
TT/TC/CC
0/37.3/62.7
7.4/41.5/51.1
10.0/41.3/48.7
Recessive
0.018
0.090
—
0.458
1.000
0.72 (0.30–1.72)
(CC + TC versus TT)
CD, Crohn’s disease; UC, ulcerative colitis; SNP, single nucleotide polymorphism; , corrected P value; OR, odds ratio; 95% CI, 95% confidence interval. The model with the smallest Akaike’s information criterion value was defined as the best model for each SNP.
