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Disease Markers
Volume 2016, Article ID 6762825, 7 pages
http://dx.doi.org/10.1155/2016/6762825
Research Article

Circulating Omentin-1 Levels Are Decreased in Dilated Cardiomyopathy Patients with Overt Heart Failure

1Department of Cardiology, The People’s Hospital of Guangxi Zhuang Autonomous Region, Nanning 530021, China
2Department of Cardiology, The People’s Hospital of Juxian, Juxian 276500, China
3Department of Cardiology, Beijing Anzhen Hospital, Capital Medical University, Beijing Institute of Heart, Lung, and Blood Vessel Disease, The Key Laboratory of Remodeling-Related Cardiovascular Disease, Ministry of Education, Beijing 100029, China
4Department of Cardiology, China-Japan Friendship Hospital of Ministry of Health, Beijing 100029, China

Received 5 March 2016; Accepted 28 April 2016

Academic Editor: Massimiliano M. Corsi Romanelli

Copyright © 2016 Ying Huang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Background. Recent evidence demonstrated that the circulating levels of omentin-1 are related to the presence of ischemic heart disease and heart failure. However, omentin-1 plasma levels in patients with nonischemic dilated cardiomyopathy (DCM), which is the most common etiology of heart failure, have yet to be investigated. Methods. Plasma levels of omentin-1 and adiponectin were measured in 100 patients with DCM and 45 healthy controls. Results. Plasma omentin-1 levels significantly decreased in DCM patients compared with the control group, whereas adiponectin levels significantly increased in DCM patients compared with the control group. Plasma omentin-1 levels were negatively correlated with adiponectin (, ), C-reactive protein (CRP) (, ), and N-terminal pro-brain natriuretic peptide (NT-proBNP) (, ) levels as well as left ventricular end-diastolic diameter (LVEDD) (, ) but were positively correlated with left ventricular ejection fraction (LVEF) (, ). Plasma adiponectin levels were positively correlated with CRP (, ) and NT-proBNP (, ) levels but were negatively correlated with fasting glucose (, ) and LVEF (, ) levels. Furthermore, omentin-1 (OR 0.983, 95% CI 0.970 to 0.996; ) levels were independently associated with the presence of DCM before NT-proBNP was added. Conclusions. Omentin-1 is a novel biomarker of DCM.