The Prognostic Role of SIRT1-Autophagy Axis in Gastric Cancer

Table 2

Multivariate analysis of the related factors of the Beclin-1 and SIRT1 high expression in GC.

Related factors	OR	95% CI	p
High Beclin-1 expression
Tumor size (5 versus 5 cm)	7.211	(1.382, 37.632)
Histologic grade (PD versus WD and MD)	2.020	(0.495, 8.249)	0.327
LN metastasis (Positive versus Negative)	5.567	(0.548, 56.539)	0.147
TNM stage (III and IV versus I and II)	3.156	(0.416, 23.917)	0.266
VCE (Positive versus Negative)	1.682	(0.502, 5.635)	0.399
SIRT1 expression (High versus Low)	4.617	(1.416, 15.053)
High SIRT1 expression
Age (60 versus 60 y)	3.016	(0.969, 9.387)	0.057
Tumor size (5 versus 5 cm)	1.564	(0.430, 5.691)	0.498
Histologic grade (PD versus WD and MD)	0.978	(0.274, 3.492)	0.973
LN metastasis (Positive versus Negative)	7.261	(0.657, 80.181)	0.106
Tumor invasion (AGC versus EGC)	9.835	(0.607, 159.346)	0.108
TNM stage (III and IV versus I and II)	0.469	(0.055, 3.988)	0.488
Beclin1 expression (High versus Low)	7.818	(1.987, 30.756)

LN metastasis, lymph node metastasis; TNM stage, tumor node metastasis stage; VCE, vascular cancer embolus; WD, well differentiation; MD, middle differentiation; PD, poor differentiation; EGC, early gastric cancer; AGC, advantage gastric cancer; OR, odd ratio; CI, confidence interval; .