Oxidative Stress-Related Biomarkers in Postmenopausal Osteoporosis: A Systematic Review and Meta-Analyses

Table 1

The characteristics of the included studies.

Location	Study design	Sample (patients/controls)	Age (patients/controls)	BMI (patients/controls)	Biomarker
Cervellati et al., Italy [34]	Cross-sectional study	56 versus 38	58.40 ± 4.30 versus 53.70 ± 4.60	24.20 ± 3.20 versus 26.40 ± 4.10	HY, AOPP,; PON-1, TAP; Ceruloplasmin thiols
Cervellati et al., Italy [6]	Cross-sectional study	30 versus 98	57.70 ± 4.9 versus 53.90 ± 5.00	24.40 ± 3.50 versus 25.40 ± 3.50	AOPP; HY
Altindag et al. [21], Turkey	Cross-sectional study	39 versus 26	56.70 ± 9.4 versus 54.15 ± 58	27.40 ± 5.20 versus 26.50 ± 4.20	TOS; TAS
Yilmaz and Eren [22], Turkey	Cross-sectional study	34 versus 15	55.90 ± 6.5 versus 54.10 ± 4.7	21.40 ± 3.10 versus 26.10 ± 2.60	Hcy; TPx; TAS
Yousefzadeh et al. [23], Iran	Cross-sectional study	22 versus 22	59.27 ± 4.26 versus 56.91 ± 6.23	25.39 ± 5.03 versus 27.47 ± 3.88	TBARS; TAP
Akpolat et al. [24], Turkey	Cross-sectional study	66 versus 60	62.88 ± 6.59 versus 55.40 ± 7.88	27.29 ± 4.06 versus 32.02 ± 8.05	Hcy; MDA; NO; Folate
Ozgocmen et al. [18], Turkey	Cross-sectional study	59 versus 22	56.75 ± 5.38 versus 55.86 ± 6.01		SOD; GSH-Px; CAT; MDA
Sendur et al. [25], Turkey	Cross-sectional study	45 versus 42	55.60 ± 2.90 versus 56.60 ± 2.40	29.40 ± 4.40 versus 27.90 ± 4.30	CAT; GR; GSH; MDA
Zinnuroglu et al. [26], Turkey	Cross-sectional study	23 versus 23	67.60 ± 8.50 versus 62.24 ± 7.60	29.21 ± 4.13 versus 28.45 ± 4.42	MDA; GPX; SOD
Ouzzif et al. [27], Morocco	Cross-sectional study	58 versus 64	61.90 ± 9.90 versus 53.50 ± 5.30	28.50 ± 4.40 versus 32.30 ± 6.20	Hcy; VB12; Folate
Bozkurt et al. [28], Turkey	Cross-sectional study	38 versus 48	57.30 ± 7.90 versus 51.40 ± 8.90	25.70 ± 3.80 versus 28.20 ± 3.70	Hcy; VB12; Folate
Haliloglu et al. [29],Turkey	Cross-sectional study	25 versus 53	55.70 ± 0.50 versus 53.50 ± 0.60	26.60 ± 5.83 versus 28.20 ± 5.19	Hcy; Folate; VB12
Baines et al. [30], UK	Cross-sectional study	110 versus 110	68.90 (41–86) versus 67.60 (45–84)	24.52 ± 4.09 versus 27.84 ± 4.96	Hcy; Folate; VB12; VB6
Cagnacci et al. [31], Italy	Cross-sectional study	28 versus 72	54.70 ± 0.90 versus 52.50 ± 0.60	25.60 ± 0.80 versus 27.50 ± 0.60	Hcy; Folate; VB12
Maggio et al. [15], Italy	Cross-sectional study	75 versus 75	70.40 ± 8.50 versus 68.80 ± 3.50	25.30 ± 2.90 versus 28.10 ± 3.40	VB A; VB C; VB E; GPx; SOD; MDA
Sharma et al. [32], India	Cross-sectional study	35 versus 30	58.00 ± 6.00 versus 53.00 ± 5.00	28.29 ± 7.50 versus 29.79 ± 6.20	SOD; CAT; GPx; TAP
Wu et al. [33], China	Cross-sectional study	60 versus 60	63.46 ± 7.45 versus 61.65 ± 6.30	23.29 ± 3.29 versus 25.39 ± 3.60	AOPP; MDA

Values are mean ± SD.
BMI: body mass index (kg/m²).