Oxidative Stress-Related Biomarkers in Postmenopausal Osteoporosis: A Systematic Review and Meta-Analyses

Table 2

The relationship between enzymatic antioxidant and risk of PO.

First author	Biomarker	Biologic sample	Sample (patients/controls)	SMD	Heterogeneity
				(95% CI)		value
Ozgocmen [18]	CAT	Erythrocytes (fasting)	59 versus 22	−1.82 (−2.39, −1.26)
Sendu [25]	CAT	Erythrocytes	45 versus 42	−0.30 (−0.72, 0.12)
SMD (95% CI)	CAT	Erythrocytes	104 versus 64	−1.05 (−2.54, 0.44)	94.4%	<0.0001
Maggio [15]	SOD	Erythrocyte	75 versus 75	−2.70 (−3.14, −2.26)
Ozgocmen [18]	SOD	Erythrocytes (fasting)	59 versus 22	0.16 (−0.33, 0.65)
SMD (95% CI)	SOD	Erythrocytes	134 versus 97	−1.27 (−4.07, 1.53)	98.6%	<0.0001
Sharma [32]	SOD	Serum	35 versus 30	−4.03 (−4.89, −3.17)
Maggio [15]	SOD	Plasma	75 versus 75	−2.05 (−2.45, −1.66)
SMD (95% CI)	SOD	Plasma/serum	110 versus 105	−3.00 (−4.94, −1.07)	94.1%	<0.0001
Maggio [15]	GPx	Plasma	75 versus 75	−2.00 (−2.39, −1.61)
Sharma [32]	GPx	Serum	35 versus 30	−5.51 (−6.59, −4.43)
SMD (95% CI)	GPx	Plasma/serum	110 versus 105	−2.41 (−2.78, −2.04)	97.2%	<0.0001