Thrombosis Related ABO, F5, MTHFR, and FGG Gene Polymorphisms in Morbidly Obese Patients
Table 3
Genotype and allele frequencies of ABO C>T (rs505922), F5 C>G (rs6427196), MTHFR C>T (rs1801133), and FGG C>T (rs6536024) SNPs in morbidly obese and nonobese control individuals.
Alleles/genotypes
Morbid obesity group ()
Control group ()
aOR
95% CI
, %
, %
rs505922 ABO C>T
T
380 (59.4)
373 (61.6)
C
260 (40.6)
233 (38.4)
1.10
(0.877–1.38)
0.406
TT
107 (35.3)
113 (37.9)
—
TC
166 (48.2)
147 (47.3)
1.26
(0.834–1.90)
0.273
CC
47 (16.5)
43 (14.7)
1.06
(0.593–1.91)
0.836
CC + TC versus TT
1.21
(0.819–1.79)
0.337
CC versus TC + TT
0.930
(0.546–1.58)
0.788
rs6427196 F5 C>G
G
610 (95.3)
571 (94.2)
C
30 (4.7)
35 (5.8)
0.805
(0.488–1.32)
0.395
GG
291 (90.8)
268 (88.7)
—
GC
28 (9.0)
35 (10.9)
0.605
(0.325–1.13)
0.112
CC
1 (0.2)
0 (0)
1.82 × 108
(0–inf)
0.999
CC + GC versus GG
0.613
(0.330–1.14)
0.120
CC versus GC + GG
1.95 × 108
(0–inf)
0.999
rs1801133 MTHFR C>T
C
447 (70.1)
447 (73.8)
T
191 (29.9)
159 (26.2)
1.201
(0.938–1.54)
0.147
CC
156 (49)
159 (54.5)
—
CT
135 (42)
129 (38.7)
1.043
(0.706–1.54)
0.832
TT
28 (8.9)
15 (6.9)
1.842
(0.837–4.05)
0.129
TT + TC versus CC
1.127
(0.775–1.64)
0.532
TT versus CT + CC
1.808
(0.838–3.90)
0.131
rs6536024 FGG C>T
T
355 (55.5)
532 (66)
C
285 (44.5)
274 (34)
0.972
(0.777–1.22)
0.804
TT
100 (30.8)
184 (43.6)
—
TC
155 (49.4)
164 (44.9)
0.796
(0.516–1.23)
0.303
CC
65 (19.8)
55 (11.6)
1.14
(0.660–1.97)
0.638
CC + TC versus TT
0.881
(0.585–1.33)
0.545
CC versus TC + TT
1.31
(0.817–2.11)
0.260
aOR, adjusted odds ratio by sex and age; CI, confidence interval.
