The Ratio of Hmox1/Nrf2 mRNA Level in the Tumor Tissue Is a Predictor of Distant Metastasis in Colorectal Cancer

Table 2

mRNA levels in the tumor and normal tissues of colorectal cancer with or without detectable Bach1 mRNA.

	Bach1 mRNA detectable		Bach1 mRNA not detectable
	n = 62		n = 22
	Normal tissue	Tumor	Normal tissue	Tumor
Nrf2	0.93 (0.82–1.03)	0.92 (0.75–1.00)	0.95 (0.68–1.42)	0.90 (0.52–1.13)
Keap1	1.00 (0.85–1.81)	1.01 (0.86–1.08)	0.98 (0.83–1.36)	0.99 (0.74–1.49)
Hmox1	0.98 (0.76–1.12)	0.92 (0.78–1.03)	1.01 (0.74–1.48)^‡	0.88 (0.56–1.10)
Bach1	0.93 (0.75–1.04)	0.94 (0.80–1.03)	—	—

Subjects with Bach1 mRNA expression detectable in both the tumor and normal tissues.
Subjects with Bach1 mRNA expression not detectable in the tumor or normal tissue.
Significantly different from the tumor tissue by Wilcoxon signed ranks test.
Significantly different from subjects with detectable Bach1 mRNA expression by Mann–Whitney test.