Expression Pattern and Clinicopathological Relevance of the Indoleamine 2,3-Dioxygenase 1/Tryptophan 2,3-Dioxygenase Protein in Colorectal Cancer

Table 3

Association of serum Kyn and Trp levels and clinical parameters of CRC patients.

Parameters	Kyn (nM)	value	Trp (M)	p value
Age
≦65	2244.16 ± 993.16	0.045	56.84 ± 17.50	0.198
>65	2950.58 ± 2007.58		53.67 ± 18.45
Gender
Female	2631.06 ± 2078.19	0.073	54.20 ± 20.27	0.482
Male	2592.51 ± 924.06		56.30 ± 15.07
Stage
Early	2574.66 ± 1167.26	0.629	57.62 ± 21.73	0.453
Late	2631.33 ± 1824.91		54.02 ± 15.95
T factor
1 and 2	2064.54 ± 724.21	0.202	63.13 ± 15.93	0.052
3 and 4	2714.12 ± 1736.76		53.72 ± 18.03
N factor
0	2346.26 ± 974.23	0.444	59.31 ± 19.74	0.063
1 and 2	2767.54 ± 1908.39		52.79 ± 16.57
M factor
0	2526.99 ± 1407.94	0.548	55.65 ± 17.91	0.747
1	3080.34 ± 2568.14		52.64 ± 18.78
IDO1
−	2756.97 ± 1804.15	0.459	53.77 ± 15.04	0.683
+	2525.70 ± 1534.37		56.04 ± 19.61
TDO2
−	2483.46 ± 998.84	0.685	52.88 ± 14.86	0.356
+	2703.55 ± 1966.34		56.79 ± 19.83
MSI
Low	2476.90 ± 1773.02	0.037	56.06 ± 18.04	0.291
High	3102.20 ± 1322.23		58.88 ± 15.36

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