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Disease Markers
Volume 2016 (2016), Article ID 8246839, 7 pages
http://dx.doi.org/10.1155/2016/8246839
Research Article

Redox Status of β2GPI in Different Stages of Diabetic Angiopathy

1Key Laboratory of Hormones and Development (Ministry of Health), Tianjin Key Laboratory of Metabolic Diseases, Tianjin Metabolic Diseases Hospital & Tianjin Institute of Endocrinology, Tianjin Medical University, Tianjin 300070, China
2Tianjin Haibin People’s Hospital, Tianjin, China

Received 16 June 2016; Accepted 9 August 2016

Academic Editor: Giuseppe Murdaca

Copyright © 2016 Jun Ma et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

We explored the redox status of beta 2 glycoprotein I (β2GPI) in different stages of diabetic angiopathy. Type 2 diabetes mellitus (T2DM) had a significantly lower proportion of reduced β2GPI as compared to healthy controls (). There was a trend that the mild coronal atherosclerosis heart disease (CAD) had higher proportion of reduced β2GPI than non-CAD and severe-CAD groups, however without significances (). The mild-A-stenosis group and mild-diabetic retinopathy (DR) groups had higher proportion of reduced β2GPI than their severely affected counterparts. The mild-slow nerve conduction velocity (NCVS) group had higher proportion of reduced β2GPI than normal nerve conduction velocity (NCVN group) and severe-NCVS groups. The proportion of reduced β2GPI was in positive correlation with 24 h urine microalbumin and total urine protein, and the proportion of reduced β2GPI was in negative correlation with serum and skin advanced glycation end products (AGEs). Taken together, our data implicate that the proportion of reduced β2GPI increased in the early stage of angiopathy and decreased with the aggravation of angiopathy.