The Effect of Poly(ADP-ribose) Polymerase-1 Gene 3′Untranslated Region Polymorphism in Colorectal Cancer Risk among Saudi Cohort

Table 4

Genotype frequencies of PARP-1 gene polymorphism in colorectal cancer and controls based on gender.

Genotype	CRC	Controls	OR	(95% CI)	value	value	Corrected value
	Male
TT	62 (0.56)	59 (0.52)	Ref
TC	38 (0.35)	48 (0.42)	0.753	0.432–1.313	1.00	0.31692	0.63384
CC	10 (0.09)	7 (0.06)	1.359	0.486–3.806	0.34	0.55777	1
TC + CC	48 (0.44)	55 (0.48)	0.830	0.491–1.406	0.48	0.48895	0.9779
T	162 (0.74)	166 (0.73)	Ref
C	58 (0.26)	62 (0.27)	0.959	0.631–1.457	0.04	0.84292	1
	Female
TT	49 (0.67)	31 (0.42)	Ref
TC	22 (0.30)	36 (0.49)	0.387	0.193–0.775	7.32	0.00682	0.01364
CC	2 (0.03)	7 (0.09)	0.181	0.035–0.927	5.04	0.02482	0.04964
TC + CC	24 (0.33)	43 (0.58)	0.353	0.180–0.692	9.43	0.00213	0.00426
T	120 (0.82)	98 (0.66)	Ref
C	26 (0.18)	50 (0.34)	0.425	0.247–0.732	9.79	0.00176	0.00352

Bonferroni corrected value.