The Effect of Poly(ADP-ribose) Polymerase-1 Gene 3′Untranslated Region Polymorphism in Colorectal Cancer Risk among Saudi Cohort

Table 5

Genotype frequencies of PARP-1 gene polymorphism in colorectal cancer and controls based on tumor location.

Genotype	Tumor	Controls	OR	(95% CI)	value	value	Corrected value
	Colon
TT	64 (0.61)	90 (0.47)	Ref
TC	35 (0.33)	86 (0.45)	0.572	0.345–0.950	4.69	0.03028	0.06056
CC	6 (0.06)	14 (0.7)	0.603	0.220–1.652	0.98	0.32134	0.64268
TC + CC	41 (0.39)	100 (0.52)	0.577	0.355–0.936	5.00	0.02533	0.05066
T	163 (0.78)	266 (0.70)	Ref
C	47 (0.22)	114 (0.30)	0.673	0.455–0.995	3.96	0.04668	0.09336
	Rectum	Controls
TT	41 (0.63)	90 (0.47)	Ref
TC	20 (0.31)	86 (0.45)	0.510	0.277–0.940	4.74	0.02954	0.05908
CC	4 (0.06)	14 (0.7)	0.627	0.194–2.023	0.62	0.43167	0.86334
TC + CC	24 (0.37)	100 (0.52)	0.527	0.295–0.940	4.78	0.02873	0.05746
T	102 (0.78)	266 (0.70)	Ref
C	28 (0.22)	114 (0.30)	0.641	0.399–1.027	3.45	0.06318	0.12636

Bonferroni corrected value.